(Q35628888)

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Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).

scientific article published on 5 October 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

multiple myeloma

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inferred from title

Kenneth C. Anderson

11

object named as

Kenneth C Anderson

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Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Klaus Podar

1

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Europe PubMed Central

PubMed publication ID

9 August 2017

Marc S Raab

2

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9 August 2017

Jing Zhang

3

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Europe PubMed Central

PubMed publication ID

9 August 2017

Douglas McMillin

4

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Europe PubMed Central

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9 August 2017

Iris Breitkreutz

5

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Europe PubMed Central

PubMed publication ID

9 August 2017

Yu-Tzu Tai

6

1 reference

Europe PubMed Central

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9 August 2017

Boris K Lin

7

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Europe PubMed Central

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9 August 2017

Nikhil Munshi

8

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9 August 2017

Teru Hideshima

9

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9 August 2017

Dharminder Chauhan

10

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9 August 2017

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publication date

5 October 2006

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Europe PubMed Central

PubMed publication ID

9 August 2017

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Europe PubMed Central

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9 August 2017

109

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9 August 2017

4

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9 August 2017

1669-1677

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Europe PubMed Central

PubMed publication ID

9 August 2017

Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Thalidomide and lenalidomide in the treatment of multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Proteasome inhibition: novel therapy for multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Nuclear protein kinase C.

1 reference

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12 July 2018

FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

1 reference

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12 July 2018

Wnts induce migration and invasion of myeloma plasma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib

1 reference

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12 July 2018

The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications

1 reference

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12 July 2018

LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Discovery and prospect of protein kinase C research: epilogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

1 reference

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12 July 2018

Protein kinase C inhibitors as novel anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Regulation of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C: a novel target for inhibiting gastric cancer cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C--a question of specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C and lipid signaling for sustained cellular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C: structure, function, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Studies and perspectives of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Tumor-promoting phorbol esters induce angiogenesis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Abnormal behavior of protein kinase C in the human myeloma cell line, RPMI 8226.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

Protein kinase C, calcium and phospholipid degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

12 July 2018

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

Antiangiogenic effects of a protein kinase Cbeta-selective small molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794057

25 September 2018

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

1 reference

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25 September 2018

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17023575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-08-042747

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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