(Q35629489)

9 August 2017

title

NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice (English)

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9 August 2017

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9

Michael Karin

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9 August 2017

Sunshin Kim

1

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9 August 2017

Isabelle Millet

2

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9 August 2017

Hun Sik Kim

3

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9 August 2017

Ja Young Kim

4

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9 August 2017

Myoung Sook Han

5

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9 August 2017

Moon-Kyu Lee

6

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9 August 2017

Kwang-Won Kim

7

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9 August 2017

Robert S Sherwin

8

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9 August 2017

Myung-Shik Lee

10

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9 August 2017

language of work or name

English

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publication date

31 January 2007

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

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9 August 2017

volume

104

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9 August 2017

issue

6

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9 August 2017

page(s)

1913-1918

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Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

9 August 2017

cites work

1 reference

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RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

12 July 2018

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IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation

12 July 2018

1 reference

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Caspase-mediated p65 cleavage promotes TRAIL-induced apoptosis

12 July 2018

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

12 July 2018

1 reference

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IKK-beta links inflammation to obesity-induced insulin resistance

12 July 2018

1 reference

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Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion.

12 July 2018

1 reference

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

12 July 2018

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Missing pieces in the NF-kappaB puzzle

12 July 2018

1 reference

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NF-kappaB signals induce the expression of c-FLIP.

12 July 2018

1 reference

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Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis

12 July 2018

1 reference

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Expression of a dominant negative inhibitor of NF-kappaB protects MIN6 beta-cells from cytokine-induced apoptosis

12 July 2018

1 reference

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IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells

12 July 2018

1 reference

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

12 July 2018

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In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

12 July 2018

1 reference

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Mechanisms of beta cell death in diabetes: a minor role for CD95.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Beta cell apoptosis in T cell-mediated autoimmune diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

The role of interleukin-1 in the pathogenesis of IDDM.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Caspase-1 is not required for type 1 diabetes in the NOD mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Administration of NF-kappaB decoy inhibits pancreatic activation of NF-kappaB and prevents diabetogenesis by alloxan in mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794308

The role of Fas in autoimmune diabetes

15 November 2018

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes

1 reference

12 December 2020

TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes

1 reference

12 December 2020

Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved

1 reference

12 December 2020

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

1 reference

12 December 2020

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

12 December 2020

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

1 reference

12 December 2020

Nuclear Factor κB Protects Pancreatic β-Cells From Tumor Necrosis Factor-α-Mediated Apoptosis

1 reference

12 December 2020

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

12 December 2020

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans

1 reference

12 December 2020

Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0610690104

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9 August 2017

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9 August 2017

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