(Q35636969)

9 August 2017

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title

Cancer pharmacogenetics: polymorphisms, pathways and beyond (English)

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9 August 2017

Cornelia M Ulrich

1

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9 August 2017

Kim Robien

series ordinal

2

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9 August 2017

Howard L McLeod

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

1 December 2003

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9 August 2017

Nature Reviews Cancer

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9 August 2017

3

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9 August 2017

912-920

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9 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc1233

9 August 2017

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Pharmacogenetics and folate metabolism -- a promising direction

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Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs

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The pharmacogenetics of codeine hypoalgesia.

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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

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Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

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The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics

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Can dihydropyrimidine dehydrogenase impact 5-fluorouracil-based treatment?

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Implications of dihydropyrimidine dehydrogenase on 5-fluorouracil pharmacogenetics and pharmacogenomics.

31 March 2020

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Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

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UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

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SNP databases and pharmacogenetics: great start, but a long way to go.

31 March 2020

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A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

31 March 2020

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5-Fluorouracil: mechanisms of action and clinical strategies

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Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

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Capecitabine: a review of its use in the treatment of advanced or metastatic colorectal cancer

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Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

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Uracil misincorporation in human DNA detected using single cell gel electrophoresis.

31 March 2020

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Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

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Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

31 March 2020

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Novel thymidylate synthase enhancer region alleles in African populations

31 March 2020

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Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase

31 March 2020

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Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

31 March 2020

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Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels

31 March 2020

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Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia

31 March 2020

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A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

31 March 2020

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Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

31 March 2020

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Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

31 March 2020

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B-vitamin intake, metabolic genes, and colorectal cancer risk (United States).

31 March 2020

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Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida

31 March 2020

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5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.

31 March 2020

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Thermolabile methylenetetrahydrofolate reductase in coronary artery disease

31 March 2020

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A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?

31 March 2020

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A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity

31 March 2020

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A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

31 March 2020

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Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.

31 March 2020

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A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

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Biological and clinical implications of the MTHFR C677T polymorphism

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MTHFR (C677T) polymorphisms and stage III colon cancer: response to therapy

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Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

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Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia

31 March 2020

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Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate

31 March 2020

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Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

31 March 2020

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MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF)

31 March 2020

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Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia

31 March 2020

1 reference

Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Using genome-wide mapping in the mouse to identify genes that influence drug response

31 March 2020

1 reference

Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice

31 March 2020

1 reference

Drug target validation and identification of secondary drug target effects using DNA microarrays

31 March 2020

1 reference

A gene-expression signature as a predictor of survival in breast cancer

31 March 2020

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Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

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Improving the evaluation of new cancer treatments: challenges and opportunities

31 March 2020

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Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

31 March 2020

1 reference

Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1233

1 reference

9 August 2017

1 reference