(Q35644702)

9 August 2017

title

Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice (English)

1 reference

9 August 2017

author name string

Vasudharani Devanathan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ina Hagedorn

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

David Köhler

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Katja Pexa

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Deya Cherpokova

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Madhurendra Singh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Peter Rosenberger

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Guido Stoll

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Lutz Birnbaumer

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Roland P Piekorz

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sandra Beer-Hammer

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Bernhard Nieswandt

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

5 May 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

6491-6496

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury

10 June 2020

cites work

1 reference

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Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

12 July 2018

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Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism

12 July 2018

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Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

12 July 2018

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Platelet P2Y₁₂ blockers confer direct postconditioning-like protection in reperfused rabbit hearts

12 July 2018

1 reference

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Pharmacological modulation of the inflammatory actions of platelets

12 July 2018

1 reference

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P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells

12 July 2018

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Arterial thrombosis--insidious, unpredictable and deadly

12 July 2018

1 reference

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Ischemia and reperfusion--from mechanism to translation

12 July 2018

1 reference

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Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Ischaemic stroke: a thrombo-inflammatory disease?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Platelet-leukocyte interactions in cardiovascular disease and beyond

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Antiplatelet therapies for the treatment of cardiovascular disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Mechanisms of thrombus formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Myocardial reperfusion injury.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Activation of platelet function through G protein-coupled receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Defective thrombus formation in mice lacking coagulation factor XII

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Impaired activation of murine platelets lacking G alpha(i2)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

G proteins endogenously expressed in Sf 9 cells: interactions with mammalian histamine receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

The human platelet ADP receptor activates Gi2 proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Munc13-4-mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Gαi2 is the essential Gαi protein in immune complex-induced lung disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Purification and Functional Reconstitution of the Human P2Y12Receptor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Activation of Rap1B by G(i) family members in platelets

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4443332

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2)

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1505887112

Clopidogrel inhibits platelet-leukocyte adhesion and platelet-dependent leukocyte activation

21 January 2018

1 reference

12 December 2020

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

1 reference

12 December 2020

Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury

1 reference

12 December 2020

A tail vein bleeding time model and delayed bleeding in hemophiliac mice

1 reference

12 December 2020

Defective macrophage migration in Gαi2- but not Gαi3-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1505887112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25944935%20AND%20SRC:MED&resulttype=core&format=json