(Q35645901)

9 August 2017

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title

Pharmacogenetic aspects of drug-induced torsade de pointes: potential tool for improving clinical drug development and prescribing (English)

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9 August 2017

Rashmi R Shah

1

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9 August 2017

publication date

1 January 2004

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9 August 2017

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9 August 2017

volume

27

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9 August 2017

issue

3

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9 August 2017

page(s)

145-172

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Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases

9 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00002018-200427030-00001

Single- and multiple-dose pharmacokinetics of R-(-)-and S-(+)-prenylamine in man.

21 January 2018

1 reference

12 December 2020

Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel

1 reference

12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

1 reference

12 December 2020

Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death

1 reference

12 December 2020

QT interval prolongation as predictor of sudden death in patients with myocardial infarction

1 reference

12 December 2020

Torsade de pointes due to quinidine: observations in 31 patients

1 reference

12 December 2020

Torsades de pointe. Apropos of 60 cases

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system

1 reference

12 December 2020

Slow hydroxylation of nortriptyline and concomitant poor debrisoquine hydroxylation: clinical implications

1 reference

12 December 2020

Concomitant use of antipsychotics and drugs that may prolong the QT interval

1 reference

12 December 2020

Postmarketing drug dosage changes of 499 FDA-approved new molecular entities, 1980-1999.

1 reference

12 December 2020

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

1 reference

12 December 2020

The significance of QT interval in drug development

1 reference

12 December 2020

Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin

1 reference

12 December 2020

Role of alpha1-blockade in congenital long QT syndrome: investigation by exercise stress test

1 reference

12 December 2020

Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the working group on arrhythmias of the european society of cardiology

1 reference

12 December 2020

Serotonin transporter gene polymorphism and antidepressant response

1 reference

12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

12 December 2020

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

1 reference

12 December 2020

Low penetrance in the long-QT syndrome: clinical impact

1 reference

12 December 2020

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram

1 reference

12 December 2020

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences

1 reference

12 December 2020

The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine

1 reference

12 December 2020

DHPLC analysis of potassium ion channel genes in congenital long QT syndrome

1 reference

12 December 2020

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

1 reference

12 December 2020

Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity

1 reference

12 December 2020

Cardiotoxicity of fluoroquinolones

1 reference

12 December 2020

Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density

1 reference

12 December 2020

High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands.

1 reference

12 December 2020

Terodiline in angina pectoris--a controlled study of a new drug

1 reference

12 December 2020

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1 reference

12 December 2020

An apparent fatal overdose of terodiline

1 reference

12 December 2020

Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity

1 reference

12 December 2020

Is there a genetic factor in flecainide toxicity?

1 reference

12 December 2020

Molecular and cellular mechanisms of cardiac arrhythmias

1 reference

12 December 2020

Terodiline for treating detrusor instability in elderly people

1 reference

12 December 2020

Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

1 reference

12 December 2020

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

1 reference

12 December 2020

[Prolonged QTc intervals in Parkinson's disease--relation to sudden death and autonomic dysfunction]

1 reference

12 December 2020

Correlation of genetic etiology with response to beta-adrenergic blockade among symptomatic patients with familial long-QT syndrome

1 reference

12 December 2020

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

1 reference

12 December 2020

Cisapride and fatal arrhythmia

1 reference

12 December 2020

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

1 reference

12 December 2020

Prolonged QT interval with halofantrine

1 reference

12 December 2020

[A new, rapid and robust genotyping method for CYP2C9 and MDR1]

1 reference

12 December 2020

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

1 reference

12 December 2020

Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation

1 reference

12 December 2020

Sotalol, hypokalaemia, syncope, and torsade de pointes

1 reference

12 December 2020

Mechanism of cardiotoxicity of halofantrine

1 reference

12 December 2020

Effect of age and overweight on the QT interval and the prevalence of long QT syndrome in children

1 reference

12 December 2020

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy

1 reference

12 December 2020

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

1 reference

12 December 2020

Inherited Arrhythmic Disorders in Japan

1 reference

12 December 2020

Potassium channel down-regulation in heart failure

1 reference

12 December 2020

Drug-induced QT prolongation in women during the menstrual cycle

1 reference

12 December 2020

Familial hypertrophic cardiomyopathy associated with prolongation of the QT interval

1 reference

12 December 2020

Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis

1 reference

12 December 2020

Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients

1 reference

12 December 2020

Stereoselective cardiotoxic effects of terodiline

1 reference

12 December 2020

Thioridazine and severe cardiac arrhythmia

1 reference

12 December 2020

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

1 reference

12 December 2020

Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long-QT syndrome.

1 reference

12 December 2020

Torsades de pointes complicating treatment with terodiline

1 reference

12 December 2020

Altered ventricular repolarization during hypoglycaemia in patients with diabetes

1 reference

12 December 2020

Dose discrepancies between the Physicians' Desk Reference and the medical literature, and their possible role in the high incidence of dose-related adverse drug events

1 reference

12 December 2020

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

1 reference

12 December 2020

Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease

1 reference

12 December 2020

Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent

1 reference

12 December 2020

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

1 reference

12 December 2020

Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families

1 reference

12 December 2020

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.

1 reference

12 December 2020

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

1 reference

12 December 2020

Molecular basis of ethnic differences in drug disposition and response

1 reference

12 December 2020

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

1 reference

12 December 2020

Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family

1 reference

12 December 2020

Cardiac effects of antimalarial treatment with halofantrine

1 reference

12 December 2020

Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type

1 reference

12 December 2020

Exploring the hidden danger of noncardiac drugs

1 reference

12 December 2020

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

12 December 2020

The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome

1 reference

12 December 2020

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1 reference

12 December 2020

ECG changes during haloperidol and pimozide treatment of Tourette's disorder

1 reference

12 December 2020

Pharmacogenetics of classical and new antipsychotic drugs

1 reference

12 December 2020

Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations

1 reference

12 December 2020

Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus

1 reference

12 December 2020

Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects

1 reference

12 December 2020

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

12 December 2020

Current pharmacogenomic approaches to clinical drug development

1 reference

12 December 2020

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence.

1 reference

12 December 2020

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

1 reference

12 December 2020

Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors

1 reference

12 December 2020

Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

1 reference

12 December 2020

Pharmacogenomics: unlocking the human genome for better drug therapy

1 reference

12 December 2020

Severe ventricular arrhythmia following parenteral administration of vincamine. Predisposing factors in 6 cases

1 reference

12 December 2020

Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A.

1 reference

12 December 2020

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

1 reference

12 December 2020

Torsades de pointes associated with drugs and toxins: recognition and management

1 reference

12 December 2020

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine

1 reference

12 December 2020

Oxidation phenotype--a major determinant of metoprolol metabolism and response

1 reference

12 December 2020

Contraindicated use of cisapride: impact of food and drug administration regulatory action

1 reference

12 December 2020

Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia

1 reference

12 December 2020

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

1 reference

12 December 2020

Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.

1 reference

12 December 2020

Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population

1 reference

12 December 2020

Time trends in the coprescribing of cisapride and contraindicated drugs in Umbria, Italy

1 reference

12 December 2020

Pharmacogenetics and adverse drug reactions

1 reference

12 December 2020

Effects of gonadal steroids on ventricular repolarization and on the response to E4031

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Severe cardiac arrythmia on cisapride

1 reference

12 December 2020

Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride

1 reference

12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

1 reference

12 December 2020

Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test

1 reference

12 December 2020

Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse

1 reference

12 December 2020

Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6

1 reference

12 December 2020

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1 reference

12 December 2020

Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics.

1 reference

12 December 2020

In vitro analysis of Ca-antagonistic effects of prenylamine as mechanisms for its cardiac actions

1 reference

12 December 2020

Prolongation of the QT interval and the sudden infant death syndrome

1 reference

12 December 2020

Molecular genetics of the long QT syndrome: Two novel mutations of the KVLQT1 gene and phenotypic expression of the mutant gene in a large kindred

1 reference

12 December 2020

Alpha-adrenoceptor stimulation and blockade modulates cesium-induced early afterdepolarizations and ventricular tachyarrhythmias in dogs

1 reference

12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1 reference

12 December 2020

Risk stratification in the long-QT syndrome.

1 reference

12 December 2020

Hypotensive response to debrisoquine and hydroxylation phenotype

1 reference

12 December 2020

Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes

1 reference

12 December 2020

Torsade de pointes induced by terfenadine in a patient with long QT syndrome

1 reference

12 December 2020

The influence of CYP2D6 polymorphism on the antiarrhythmic efficacy of propafenone in patients with paroxysmal atrial fibrillation during 3 months propafenone prophylactic treatment.

1 reference

12 December 2020

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

1 reference

12 December 2020

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans

1 reference

12 December 2020

Basic mechanisms underlying prenylamine-induced 'torsade de pointes': differences between prenylamine and fendiline due to basic actions of the isomers

1 reference

12 December 2020

Testosterone-mediated modulation of HERG blockade by proarrhythmic agents

1 reference

12 December 2020

Oxidation phenotyping in alcoholics with liver disease of varying severity

1 reference

12 December 2020

Long QTc and Torsades de Pointes in Human Immunodeficiency Virus Disease

1 reference

12 December 2020

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

1 reference

12 December 2020

[Torsade de pointes. Apropos of 54 cases]

1 reference

12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Malignant ventricular tachyarrhythmias associated with the use of encainide

1 reference

12 December 2020

KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome

1 reference

12 December 2020

Twenty single-nucleotide polymorphisms in four genes encoding cardiac ion channels

1 reference

12 December 2020

Drug-induced prolongation of the QT interval: why the regulatory concern?

1 reference

12 December 2020

Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors

1 reference

12 December 2020

Prolonged QT and hypertrophic cardiomyopathy in two families with 10 sudden deaths.

1 reference

12 December 2020

Pharmacogenetics of cardiac K(+) channels

1 reference

12 December 2020

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1 reference

12 December 2020

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

1 reference

12 December 2020

Impaired oxidation of debrisoquine in patients with perhexiline liver injury

1 reference

12 December 2020

Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence

1 reference

12 December 2020

Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors

1 reference

12 December 2020

Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide

1 reference

12 December 2020

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

1 reference

12 December 2020

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine

1 reference

12 December 2020

Torsade de pointes after astemizole overdose.

1 reference

12 December 2020

Development of simplified and rapid detection assay for genetic polymorphisms influencing drug response and its clinical applications

1 reference

12 December 2020

Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose

1 reference

12 December 2020

The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice

1 reference

12 December 2020

Compound heterozygosity for mutations (W156X and R225W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system

1 reference

12 December 2020

Prolonged QT interval in hypertrophic and dilated cardiomyopathy in children

1 reference

12 December 2020

Cytochrome p450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions

1 reference

12 December 2020

Phenformin-induced lacticacidosis associated with impaired debrisoquine hydroxylation

1 reference

12 December 2020

Pharmacokinetic Interaction of Fluvoxamine and Thioridazine in Schizophrenic Patients

1 reference

12 December 2020

Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

1 reference

12 December 2020

Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Clinical safety profile of sotalol in the treatment of arrhythmias

1 reference

12 December 2020

Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alpha1-adrenoceptor stimulation

1 reference

12 December 2020

Pharmacogenetics of the major polymorphic metabolizing enzymes.

1 reference

12 December 2020

Genetic polymorphisms of the human MDR1 drug transporter

1 reference

12 December 2020

Torsades de pointes ventricular tachycardia and terodiline

1 reference

12 December 2020

QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients

1 reference

12 December 2020

Greater quinidine-induced QTc interval prolongation in women

1 reference

12 December 2020

QT interval prolongation and mortality in type 1 diabetic patients: a 5-year cohort prospective study. Neuropathy Study Group of the Italian Society of the Study of Diabetes, Piemonte Affiliate

1 reference

12 December 2020

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

1 reference

12 December 2020

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

1 reference

12 December 2020

Abnormalities of the QT interval in primary disorders of autonomic failure

1 reference

12 December 2020

Are there sex-specific differences in ventricular repolarization or in drug-induced early afterdepolarizations in isolated rabbit purkinje fibers?

1 reference

12 December 2020

Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome

1 reference

12 December 2020

Pharmacological differentiation of classical and novel antipsychotics

1 reference

12 December 2020

Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population

1 reference

12 December 2020

Prolonged QT interval with halofantrine

1 reference

12 December 2020

Cloning and functional expression of a human liver organic cation transporter

1 reference

12 December 2020

Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation

1 reference

12 December 2020

Pharmacokinetics of R(+)-terodiline given intravenously and orally to healthy volunteers

1 reference

12 December 2020

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone

1 reference

12 December 2020

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

1 reference

12 December 2020

Repeated syncopes during prolonged treatment with prenylamine (Segontine 60)

1 reference

12 December 2020

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

1 reference

12 December 2020

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

1 reference

12 December 2020

10.2165/00002018-200427030-00001

Identifiers

DOI

1 reference

Dimensions Publication ID

9 August 2017

1034494526

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