(Q35669634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

4

1 reference

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25 December 2019

Michael R Baldwin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

Lisa M Eubanks

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Mark S Hixon

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Wei Jin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Colin M Clancy

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

William H Tepp

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Carl J Malizio

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Michael C Goodnough

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Joseph T Barbieri

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Eric A Johnson

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Dale L Boger

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Tobin J Dickerson

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Kim D Janda

14

1 reference

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25 December 2019

language of work or name

English

0 references

publication date

9 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

25 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

104

1 reference

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25 December 2019

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

2602-2607

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication

25 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Botulinum toxin: clinical use.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

A credit-card library approach for disrupting protein-protein interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

The medicinal chemistry of botulinum, ricin and anthrax toxins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Unraveling hot spots in binding interfaces: progress and challenges

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Protein functional epitopes: hot spots, dynamics and combinatorial libraries

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Development of vaccines for prevention of botulism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Conservation of polar residues as hot spots at protein interfaces

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminal

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

The atomic structure of protein-protein recognition sites

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Anatomy of hot spots in protein interfaces

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Lack of effect of Miller Fisher sera/plasmas on transmitter release from PC12 cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Protection by the heavy metal chelator N,N,N',N'-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN) against the lethal action of botulinum neurotoxin A and B.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Principles of protein-protein interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Proteolysis of SNAP-25 by types E and A botulinal neurotoxins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Shape complementarity at protein/protein interfaces

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Statistical analysis of a rapid in vivo method for the titration of the toxin of Clostridium botulinum

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Properties and use of botulinum toxin and other microbial neurotoxins in medicine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Crystal structure of botulinum neurotoxin type A and implications for toxicity

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Human botulism immune globulin for the treatment of infant botulism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Substrate recognition strategy for botulinum neurotoxin serotype A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

The C-terminus of botulinum neurotoxin type A light chain contributes to solubility, catalysis, and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Functional characterisation of tetanus and botulinum neurotoxins binding domains.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1815229

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0611213104

Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E

21 January 2018

1 reference

12 December 2020

Persistence of botulinum neurotoxin action in cultured spinal cord cells

1 reference

12 December 2020

Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I

1 reference

12 December 2020

Intimate details of the most poisonous poison

1 reference

12 December 2020

Higher order iminodiacetic acid libraries for probing protein-protein interactions

1 reference

12 December 2020

Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model

1 reference

12 December 2020

Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0611213104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17293454%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference