(Q35681628)

9 August 2017

1 reference

title

Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation (English)

1 reference

9 August 2017

Catherine F Welsh

1

1 reference

PubMed ID

14999152

9 August 2017

language of work or name

English

0 references

publication date

1 March 2004

1 reference

Breast Cancer Research and Treatment

9 August 2017

1 reference

9 August 2017

84

1 reference

9 August 2017

33-42

1 reference

9 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1023/b:brea.0000018425.31633.07

9 August 2017

0 references

cites work

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Anchorage-dependent transcription of the cyclin A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Activation of Rac and Cdc42 by integrins mediates cell spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

New functional activities for the p21 family of CDK inhibitors

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

G1 events and regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Anchorage-dependent cell cycle progression

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Growth factor activation of MAP kinase requires cell adhesion.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Geometric control of cell life and death

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Integrin-mediated signals regulated by members of the rho family of GTPases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Multiple ras effector pathways contribute to G(1) cell cycle progression

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Translational control of p27Kip1 accumulation during the cell cycle

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Transformation mediated by RhoA requires activity of ROCK kinases

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Cyclin D1 protein expression and function in human breast cancer

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Cyclin D1 and prognosis in human breast cancer.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Rho GTPases are over-expressed in human tumors.

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

1 reference

https://api.crossref.org/works/10.1023%2FB%3ABREA.0000018425.31633.07

7 January 2021

10.1023/B:BREA.0000018425.31633.07

Identifiers

DOI

1 reference

PubMed ID

14999152

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

14999152