(Q35685082)

English

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

scientific article published on 20 January 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

D H Spencer

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

M A Young

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

T L Lamprecht

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

N M Helton

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

R Fulton

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

M O'Laughlin

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

C Fronick

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

V Magrini

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

R T Demeter

9

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

C A Miller

10

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

J M Klco

11

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

R K Wilson

12

1 reference

Europe PubMed Central

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9 August 2017

T J Ley

13

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

publication date

20 January 2015

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Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1279-1289

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

https://scigraph.springernature.com/pub.10.1038/leu.2015.6

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Hox gene dysregulation in acute myeloid leukemia

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Hox in motion: tracking HoxA cluster conformation during differentiation

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells

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A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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12 July 2018

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

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12 July 2018

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

1 reference

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12 July 2018

Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

A framework for oligonucleotide microarray preprocessing.

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12 July 2018

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

1 reference

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12 July 2018

Leukemogenic transformation by HOXA cluster genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

BSMAP: whole genome bisulfite sequence MAPping program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

HOXA9 is required for survival in human MLL-rearranged acute leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

HOX expression patterns identify a common signature for favorable AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Hox genes in hematopoiesis and leukemogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

An Mll-dependent Hox program drives hematopoietic progenitor expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Identification of homeobox genes expressed in human haemopoietic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

Coordinate regulation of HOX genes in human hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

12 July 2018

The dynamic architecture of Hox gene clusters.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

Stem cell gene expression programs influence clinical outcome in human leukemia.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456213

25 September 2018

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.6

21 January 2018

Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?

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https://api.crossref.org/works/10.1038%2FLEU.2015.6

21 January 2018

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.6

21 January 2018

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

1 reference

https://pubmed.ncbi.nlm.nih.gov/25600023

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25600023

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric study of neutrophilic granulopoiesis in normal bone marrow using an expanded panel of antibodies: correlation with morphologic assessments

1 reference

https://pubmed.ncbi.nlm.nih.gov/25600023

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2015.6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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