(Q35689381)

English

Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity

scientific article published on 14 November 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 August 2017

Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

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Ronald Swanstrom

8

object named as

Ronald Swanstrom

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Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Gavin J Henderson

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Sook-Kyung Lee

2

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Europe PubMed Central

PubMed publication ID

9 August 2017

David M Irlbeck

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Janera Harris

4

1 reference

Europe PubMed Central

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9 August 2017

Melissa Kline

5

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Europe PubMed Central

PubMed publication ID

9 August 2017

Elizabeth Pollom

6

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9 August 2017

Neil Parkin

7

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9 August 2017

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publication date

14 November 2011

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Europe PubMed Central

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9 August 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

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9 August 2017

56

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Europe PubMed Central

PubMed publication ID

9 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

623-633

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs

1 reference

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Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance

1 reference

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12 July 2018

HIV-1 protease mutations and protease inhibitor cross-resistance

1 reference

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12 July 2018

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

1 reference

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The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine

1 reference

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Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection

1 reference

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Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasma

1 reference

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Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

1 reference

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Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication

1 reference

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Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults

1 reference

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Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precur

1 reference

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Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

1 reference

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HIV preferentially infects HIV-specific CD4+ T cells

1 reference

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12 July 2018

Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients

1 reference

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12 July 2018

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

1 reference

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12 July 2018

Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1.

1 reference

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12 July 2018

A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics

1 reference

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12 July 2018

Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug

1 reference

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12 July 2018

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120

1 reference

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12 July 2018

A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir

1 reference

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12 July 2018

The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

1 reference

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12 July 2018

A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1

1 reference

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12 July 2018

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

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12 July 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

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12 July 2018

Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.

1 reference

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12 July 2018

Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity.

1 reference

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Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations.

1 reference

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Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators.

1 reference

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12 July 2018

Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir.

1 reference

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12 July 2018

Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo.

1 reference

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12 July 2018

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

1 reference

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12 July 2018

Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites

1 reference

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Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors

1 reference

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12 July 2018

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

1 reference

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Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity

1 reference

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Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

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Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

1 reference

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Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease

1 reference

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Function of the cytoplasmic domain of a retroviral transmembrane protein: p15E-p2E cleavage activates the membrane fusion capability of the murine leukemia virus Env protein

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Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

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Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors

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In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease

1 reference

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Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure

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CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy

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Antiretroviral drug resistance testing in adult HIV-1 infection: recommendations of an International AIDS Society-USA Panel.

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Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants

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Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials.

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A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

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15 November 2018

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22083488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22083488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22083488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.05549-11

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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