(Q35700459)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

0 references

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

F Xing

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Y Persaud

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

C A Pratilas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

B S Taylor

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

M Janakiraman

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Q-B She

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

H Gallardo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

C Liu

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

T Merghoub

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

B Hefter

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Viale

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Heguy

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

E De Stanchina

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

D Cobrinik

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

G Bollag

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

J Wolchok

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Houghton

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

D B Solit

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

4 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

446-457

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

6 February 2020

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

12 July 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

12 July 2018

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

12 July 2018

1 reference

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12 July 2018

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Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.

12 July 2018

1 reference

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Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

12 July 2018

1 reference

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

12 July 2018

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

12 July 2018

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

12 July 2018

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

12 July 2018

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12 July 2018

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Genetic predictors of MEK dependence in non-small cell lung cancer

12 July 2018

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Functional copy-number alterations in cancer

12 July 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

12 July 2018

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

12 July 2018

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

12 July 2018

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A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

12 July 2018

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A faster circular binary segmentation algorithm for the analysis of array CGH data

12 July 2018

1 reference

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Divorcing ARF and p53: an unsettled case

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

Mechanisms of drug inhibition of signalling molecules

12 July 2018

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

BRAFE600-associated senescence-like cell cycle arrest of human naevi

12 July 2018

1 reference

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Targeting the mitogen-activated protein kinase cascade to treat cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

V599EB-RAF is an oncogene in melanocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

Mutations of the BRAF gene in human cancer

12 July 2018

1 reference

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12 July 2018

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Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors

12 July 2018

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Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.

12 July 2018

1 reference

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

1 reference

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12 July 2018

1 reference

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267014

High-throughput oncogene mutation profiling in human cancer

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2011.250

Suppression of BRAF(V599E) in human melanoma abrogates transformation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21725359

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2011.250

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725359%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference