(Q21629049)

21 August 2022

2

Christine A Pratilas

Christine A

Pratilas

1 reference

21 August 2022

6

Barry S. Taylor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

12 June 2024

Madhavi Tadi

4

Madhavi

Tadi

1 reference

21 August 2022

Weiqing Wang

5

Weiqing

Wang

1 reference

21 August 2022

Ensar Halilovic

7

Ensar

Halilovic

1 reference

21 August 2022

Yogindra Persaud

8

Yogindra

Persaud

1 reference

21 August 2022

Feng Xing

9

Feng

Xing

1 reference

21 August 2022

Agnes Viale

10

Agnes

Viale

1 reference

21 August 2022

James Tsai

11

James

Tsai

1 reference

21 August 2022

Neal Rosen

15

Neal

Rosen

1 reference

21 August 2022

Eric W. Joseph

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

12 June 2024

Poulikos I. Poulikakos

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

12 June 2024

Paul B. Chapman

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

12 June 2024

David B. Solit

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

12 June 2024

language of work or name

English

0 references

publication date

August 2010

0 references

28 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

full work available at URL

12 June 2024

http://www.pnas.org/content/107/33/14903.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20668238/?tool=EBI

12 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20668238/pdf/?tool=EBI

12 June 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://europepmc.org/articles/PMC2930420

12 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://europepmc.org/articles/PMC2930420?pdf=render

12 June 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://doi.org/10.1073/pnas.1008990107

12 June 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20668238

https://pnas.org/doi/pdf/10.1073/pnas.1008990107

12 June 2024

1 reference

Crossref

DOI

10.1073/PNAS.1008990107

https://api.crossref.org/works/10.1073/PNAS.1008990107

Proceedings of the National Academy of Sciences of the United States of America

12 June 2024

published in

0 references

volume

107

0 references

issue

33

0 references

page(s)

14903–14908

0 references

cites work

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

1 reference

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

19 March 2017

1 reference

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

19 March 2017

1 reference

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Cluster analysis and display of genome-wide expression patterns

19 March 2017

1 reference

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

19 March 2017

1 reference

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Mutations of the BRAF gene in human cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

BRAF mutation predicts sensitivity to MEK inhibition

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Mitogen-activated protein kinase pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Genetic predictors of MEK dependence in non-small cell lung cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

12 September 2017

1 reference

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

12 September 2017

1 reference

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Modulation of signalling by Sprouty: a developing story

12 September 2017

1 reference

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Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma

12 September 2017

1 reference

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins

27 September 2017

1 reference

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

27 September 2017

1 reference

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Regulation of Raf-1 by direct feedback phosphorylation.

27 September 2017

1 reference

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Paradoxical activation of Raf by a novel Raf inhibitor

27 September 2017

1 reference

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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

27 September 2017

1 reference

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Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

A negative feedback signaling network underlies oncogene-induced senescence

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2930420

BRAF and RAS mutations in human lung cancer and melanoma

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20668238

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1008990107

1 reference

ADS bibcode

2010PNAS..10714903J

0 references

1 reference

1 reference

1 reference