(Q35707736)

English

Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

scientific article published on 18 October 2011

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scholarly article

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13 February 2020

Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator (English)

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13 February 2020

natural product

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based on heuristic

inferred from title

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13 February 2020

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Mostafa I Fekry

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13 February 2020

Jozsef Szekely

2

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13 February 2020

Sanjay Dutta

3

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13 February 2020

Hong Zang

5

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13 February 2020

Kent S Gates

6

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13 February 2020

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18 October 2011

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13 February 2020

Journal of the American Chemical Society

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13 February 2020

133

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13 February 2020

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13 February 2020

17641-17651

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13 February 2020

Rapid DNA-protein cross-linking and strand scission by an abasic site in a nucleosome core particle.

1 reference

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12 July 2018

Identifying single bases in a DNA oligomer with electron tunnelling

1 reference

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12 July 2018

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

1 reference

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12 July 2018

Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells

1 reference

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12 July 2018

An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals

1 reference

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12 July 2018

Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites

1 reference

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12 July 2018

Recognition of abasic sites and single base bulges in DNA by a metalloinsertor

1 reference

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12 July 2018

Crystal structure of DNA-bound Co(III)·bleomycin B2: Insights on intercalation and minor groove binding

1 reference

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12 July 2018

Interstrand cross-links generated by abasic sites in duplex DNA.

1 reference

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12 July 2018

The reaction of mono- and di-functional alkylating agents with nucleic acids

1 reference

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12 July 2018

Sequence-selective DNA recognition: natural products and nature's lessons

1 reference

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12 July 2018

A coumarin from Mallotus resinosus that mediates DNA cleavage

1 reference

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12 July 2018

Cellular response and molecular mechanism of antitumor activity by leinamycin in MiaPaCa human pancreatic cancer cells

1 reference

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12 July 2018

Biologically relevant chemical reactions of N7-alkylguanine residues in DNA.

1 reference

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12 July 2018

Sequence specificity of DNA alkylation by the antitumor natural product leinamycin

1 reference

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12 July 2018

Structural considerations in the interaction of DNA and acridines

1 reference

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12 July 2018

Resistance to enediyne antitumor antibiotics by CalC self-sacrifice

1 reference

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12 July 2018

Antibody-targeted chemotherapy with immunoconjugates of calicheamicin

1 reference

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12 July 2018

A mechanistic perspective on the chemistry of DNA repair glycosylases

1 reference

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12 July 2018

Mechanisms of in situ activation for DNA-targeting antitumor agents

1 reference

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12 July 2018

DNA and its associated processes as targets for cancer therapy

1 reference

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12 July 2018

Distinguishing "looped-out" and "stacked-in" DNA bulge conformation using fluorescent 2-aminopurine replacing a purine base

1 reference

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12 July 2018

Curing metastatic testicular cancer

1 reference

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12 July 2018

Probing the limits of electrostatic catalysis by uracil DNA glycosylase using transition state mimicry and mutagenesis.

1 reference

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12 July 2018

Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons

1 reference

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12 July 2018

Molecular recognition of DNA by small molecules

1 reference

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12 July 2018

Selective intercalation of charge neutral intercalators into GG and CG steps: implication of HOMO-LUMO interaction for sequence-selective drug intercalation into DNA.

1 reference

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12 July 2018

The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis

1 reference

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12 July 2018

Mechanisms of DNA damage by leinamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

Crystal structure of an adenine bulge in the RNA chain of a DNA.RNA hybrid, d(CTCCTCTTC).r(gaagagagag)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

Naturally occurring alkylresorcinols that mediate DNA damage and inhibit its repair

1 reference

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12 July 2018

The influence of the exocyclic pyrimidine 5-methyl group on DNAse I cleavage and sequence recognition by drugs

1 reference

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12 July 2018

Bleomycin: new perspectives on the mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

Simultaneous determination of helical unwinding angles and intrinsic association constants in ligand-DNA complexes: the interaction between DNA and calichearubicin B.

1 reference

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12 July 2018

Mitomycin C: small, fast and deadly (but very selective)

1 reference

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12 July 2018

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity

1 reference

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12 July 2018

DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

1 reference

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12 July 2018

The enediyne antibiotics

1 reference

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12 July 2018

Sequence-selective binding of amiloride to DNA.

1 reference

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12 July 2018

Effect of 5-methylcytosine as a neighboring base on methylation of DNA guanine by N-methyl-N-nitrosourea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

DNA adducts, mutations and cancer

1 reference

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12 July 2018

Endogenous DNA adducts: potential and paradox

1 reference

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12 July 2018

Selective recognition of the m5 CpG dinucleotide sequence in DNA by mitomycin C for alkylation and cross-linking

1 reference

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12 July 2018

Criteria for the mode of binding of DNA binding agents.

1 reference

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12 July 2018

Kinking of DNA and RNA by base bulges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

DNA alkylation and unwinding induced by benzo[a]pyrene diol epoxide: modulation by ionic strength and superhelicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

12 July 2018

57 Sequencing end-labeled DNA with base-specific chemical cleavages

1 reference

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12 July 2018

Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation

1 reference

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12 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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12 July 2018

Ethidium ion binds more strongly to a DNA double helix with a bulged cytosine than to a regular double helix

1 reference

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12 July 2018

Is intercalation a critical factor in the covalent binding of mutagenic and tumorigenic polycyclic aromatic diol epoxides to DNA?

1 reference

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12 July 2018

Binding of 9-aminoacridine to bulged-base DNA oligomers from a frame-shift hot spot

1 reference

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12 July 2018

Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.

1 reference

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12 July 2018

DNA and associated targets for drug design

1 reference

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12 July 2018

Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxin B1 with the oligodeoxynucleotide d(ATGCAT)2 and with plasmid pBR322 support intercalative association with the B-DNA helix

1 reference

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12 July 2018

Selective strand scission by intercalating drugs at DNA bulges

1 reference

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12 July 2018

Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers

1 reference

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12 July 2018

Design of sequence-specific DNA-binding molecules

1 reference

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12 July 2018

DNA methylation diminishes bleomycin-mediated strand scission

1 reference

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12 July 2018

DNA sequence dependent binding modes of 4',6-diamidino-2-phenylindole (DAPI).

1 reference

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12 July 2018

Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.

1 reference

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12 July 2018

The importance of intercalation in the covalent binding of benzo(a)pyrene diol epoxide to DNA.

1 reference

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12 July 2018

Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA

1 reference

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12 July 2018

Three-dimensional structures of bulge-containing DNA fragments

1 reference

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12 July 2018

Differences in unwinding of supercoiled DNA induced by the two enantiomers of anti-benzo[a]pyrene diol epoxide

1 reference

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12 July 2018

Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix

1 reference

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12 July 2018

Covalent intercalative binding to DNA in relation to the mutagenicity of hydrocarbon epoxides and N-acetoxy-2-acetylaminofluorene

1 reference

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12 July 2018

Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.

1 reference

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25 September 2018

DNA damage by fasicularin

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25 September 2018

The structure of DNA dictates purine atom site selectivity in alkylation by primary diazonium ions

1 reference

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25 September 2018

Generation of reactive oxygen species by a persulfide (BnSSH).

1 reference

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25 September 2018

Affinity labeling of a single guanine bulge

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25 September 2018

Chemical properties of the leinamycin-guanine adduct in DNA.

1 reference

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25 September 2018

Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences

1 reference

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25 September 2018

Mechanics of DNA flexibility visualized by selective 2'-amine acylation at nucleotide bulges

1 reference

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25 September 2018

Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

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25 September 2018

Improved Chemical Strategies for the Targeted Therapy of Cancer

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25 September 2018

Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin.

1 reference

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25 September 2018

Activation of leinamycin by thiols: a theoretical study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

Thiol-independent DNA alkylation by leinamycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

Differential rates of reversibility of ecteinascidin 743-DNA covalent adducts from different sequences lead to migration to favored bonding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

DNA alkylation by leinamycin can be triggered by cyanide and phosphines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

25 September 2018

Cytosine Methylation Enhances DNA Damage Produced by Groove Binding and Intercalating Enediynes: Studies with Esperamicins A1 and C†

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268133

7 December 2018

Specific Alkylation of Guanine Opposite to a Single Nucleotide Bulge: A Chemical Probe for the Bulged Structure of DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation of a Methylated DNA Standard, and Its Stability on Storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA binding and alkylation by the "left half" of azinomycin B

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noncovalent DNA binding and the mechanism of oxidative DNA damage by fecapentaene-12

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward a human epigenome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depurinating Acylfulvene−DNA Adducts: Characterizing Cellular Chemical Reactions of a Selective Antitumor Agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Covalent modification and single-strand scission of DNA by a new antitumor antibiotic kapurimycin A3

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand scission by the novel antitumor antibiotic leinamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic studies of anthracycline-DNA interaction by fluorescence stopped flow confirm a complex association mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DC 107, a novel antitumor antibiotic produced by a Streptomyces sp

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bleomycin: Synthetic and Mechanistic Studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Letter: Unwinding the DNA helix by intercalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in the structure of deoxyribonucleic acid on chemical methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of benzo[a]pyrene diol epoxide induced deoxyribonucleic acid strand scission

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21954957

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Structure of a Novel Antitumor Antibiotic Leinamycin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1246/CL.1993.1957

Identifiers

10.1021/JA2046149

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21954957%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

release_ccixhctsmzf45kntpyutltynke

1 reference

https://api.fatcat.wiki/v0/release/ccixhctsmzf45kntpyutltynke

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21954957%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21954957%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

ResearchGate publication ID

0 references

Sitelinks

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