(Q35711858)

English

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.

scientific article published on 4 May 2010

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scholarly article

1 reference

Europe PubMed Central

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1 February 2020

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner (English)

1 reference

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1 February 2020

8

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1 February 2020

author name string

Thomas J Turbyville

1

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1 February 2020

Demirkan B Gürsel

2

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1 February 2020

Robert G Tuskan

3

1 reference

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1 February 2020

Jessica C Walrath

4

1 reference

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1 February 2020

Claudia A Lipschultz

5

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1 February 2020

Stephen J Lockett

6

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1 February 2020

David F Wiemer

7

1 reference

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1 February 2020

Karlyne M Reilly

9

1 reference

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1 February 2020

publication date

4 May 2010

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1 February 2020

Molecular Cancer Therapeutics

1 reference

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1 February 2020

9

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1 February 2020

1234-1243

1 reference

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1 February 2020

5

1 reference

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1 February 2020

Drug discovery and natural products: end of an era or an endless frontier?

1 reference

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Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma

1 reference

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Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease

1 reference

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27 July 2018

Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds

1 reference

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27 July 2018

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells

1 reference

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27 July 2018

Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells

1 reference

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27 July 2018

Cellular targets of natural products

1 reference

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27 July 2018

A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study

1 reference

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27 July 2018

Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas

1 reference

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27 July 2018

Recent developments in neurofibromatosis type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Tumor microenvironment and neurofibromatosis type I: connecting the GAPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

1 reference

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27 July 2018

The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Synthesis of nonracemic 3-deoxyschweinfurthin B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

NF1 tumor suppressor gene function: narrowing the GAP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Mouse tumor model for neurofibromatosis type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Mouse models of tumor development in neurofibromatosis type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Neurofibromatosis and childhood tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

27 July 2018

Total synthesis of (+)-schweinfurthins B and E.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

25 September 2018

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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25 September 2018

An integrated genomic analysis of human glioblastoma multiforme

1 reference

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25 September 2018

Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes.

1 reference

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25 September 2018

Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3268685

25 September 2018

Tumorigenic properties of neurofibromin-deficient Schwann cells in culture and as syngrafts in Nf1 knockout mice.

1 reference

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25 September 2018

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

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25 September 2018

Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.

1 reference

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25 September 2018

Mortality in neurofibromatosis 1: an analysis using U.S. death certificates.

1 reference

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25 September 2018

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

1 reference

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Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20442305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20442305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20442305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-09-0834

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20442305%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20442305%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20442305%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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