(Q30866998)

27 June 2017

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title

Drug discovery and natural products: end of an era or an endless frontier? (English)

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27 June 2017

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John Christopher Vederas

object named as

John C Vederas

series ordinal

2

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author name string

Jesse W-H Li

series ordinal

1

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27 June 2017

language of work or name

English

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publication date

1 July 2009

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27 June 2017

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27 June 2017

volume

325

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27 June 2017

issue

5937

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27 June 2017

page(s)

161-165

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Natural products in drug discovery

27 June 2017

cites work

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https://api.crossref.org/works/10.1126%2FSCIENCE.1168243

The evolving role of natural products in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1168243

The role of natural product chemistry in drug discovery

21 January 2018

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Combinatorial biosynthesis of reduced polyketides

21 January 2018

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Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

21 January 2018

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Plant-derived compounds in clinical trials

21 January 2018

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Animal toxins acting on voltage-gated potassium channels

21 January 2018

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Renaissance in antibacterial discovery from actinomycetes

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Deep-sea natural products

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1168243

Structure-activity relationship studies of the two-component lantibiotic haloduracin

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1168243

Marine metagenomics: strategies for the discovery of novel enzymes with biotechnological applications from marine environments

21 January 2018

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Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

21 January 2018

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Microbiology: metagenomics

21 January 2018

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High-content single-cell drug screening with phosphospecific flow cytometry

21 January 2018

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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

21 January 2018

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Engineering natural products using combinatorial biosynthesis and biocatalysis

21 January 2018

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Protein-protein interactions in multienzyme megasynthetases.

21 January 2018

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Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

21 January 2018

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Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei

21 January 2018

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Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

21 January 2018

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Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

21 January 2018

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Production and engineering of terpenoids in plant cell culture

21 January 2018

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Synthetic biology for synthetic chemistry

21 January 2018

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Real-time DNA sequencing from single polymerase molecules

21 January 2018

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Medicine. Racing forward: the Genomics and Personalized Medicine Act

21 January 2018

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Peptide leads new class of chronic pain drugs

21 January 2018

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Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1168243

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27 June 2017

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