(Q33312213)

25 July 2017

High-content single-cell drug screening with phosphospecific flow cytometry (English)

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25 July 2017

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4

Garry P Nolan

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25 July 2017

Peter O Krutzik

1

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PubMed ID

18157122

25 July 2017

Janelle M Crane

series ordinal

2

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PubMed ID

18157122

25 July 2017

Matthew R Clutter

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3

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25 July 2017

23 December 2007

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25 July 2017

Nature Chemical Biology

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25 July 2017

4

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25 July 2017

132-142

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25 July 2017

2

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https://scigraph.springernature.com/pub.10.1038/nchembio.2007.59

25 July 2017

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What's wrong with drug screening today

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Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors.

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Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events

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Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

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Mapping normal and cancer cell signalling networks: towards single-cell proteomics

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Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity.

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Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry

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Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo

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Flow cytometric analysis of cytokine receptor signal transduction

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TCR signal transduction in antigen-specific memory CD8 T cells.

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Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

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Causal protein-signaling networks derived from multiparameter single-cell data

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Flow cytometry for high-throughput, high-content screening

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High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands

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K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

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A new modality for immunosuppression: targeting the JAK/STAT pathway

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Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy.

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Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

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How many drug targets are there?

21 January 2018

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Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

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A robustness-based approach to systems-oriented drug design.

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Phospho-specific flow cytometry in drug discovery

21 January 2018

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Cytometry of the cell cycle: cycling through history

21 January 2018

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Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry

21 January 2018

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7 January 2021

Characterization of the murine immunological signaling network with phosphospecific flow cytometry

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

Increasing the power of cytometry

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

The effect of a new antibiotic, cryptosporiopsin, on RNA synthesis in L-cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

A mammalian cell agar-diffusion assay for the detection of toxic compounds

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

The mode of action of nanaomycin A in gram-positive bacteria

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

Immunosuppressive activity of streptonigrin in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

Single-cell phospho-protein analysis by flow cytometry

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.59

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.59

1 reference

25 July 2017

1 reference

PubMed ID

18157122