(Q35825869)

10 August 2017

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title

A new modality for immunosuppression: targeting the JAK/STAT pathway (English)

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10 August 2017

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John J O'Shea

1

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10 August 2017

Marko Pesu

series ordinal

2

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10 August 2017

Dominic C Borie

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3

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10 August 2017

Paul S Changelian

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4

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10 August 2017

1 July 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

555-564

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10 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd1441

10 August 2017

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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases

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The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

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A protein tyrosine kinase in the interferon alpha/beta signaling pathway

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Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

21 January 2018

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

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Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model

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Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

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Eleven novel JAK3 mutations in patients with severe combined immunodeficiency-including the first patients with mutations in the kinase domain

21 January 2018

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Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.

21 January 2018

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Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation

21 January 2018

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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 January 2018

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Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

21 January 2018

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Multiple gamma c-dependent cytokines regulate T-cell development

21 January 2018

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

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Interleukin-7: master regulator of peripheral T-cell homeostasis?

21 January 2018

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Interleukin-7: from bench to clinic

21 January 2018

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

21 January 2018

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Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells

21 January 2018

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Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

21 January 2018

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Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells

21 January 2018

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Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

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Interleukin-2 and interleukin-15: immunotherapy for cancer.

21 January 2018

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A critical role for IL-21 in regulating immunoglobulin production

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A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection.

21 January 2018

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Regulatory T cells in autoimmmunity*.

21 January 2018

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The main function of IL-2 is to promote the development of T regulatory cells

21 January 2018

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Unexpected and variable phenotypes in a family with JAK3 deficiency

21 January 2018

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Perspectives on the development of a molecularly targeted agent

21 January 2018

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

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Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154.

21 January 2018

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The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity.

21 January 2018

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Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis

21 January 2018

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Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions

21 January 2018

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Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor

21 January 2018

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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

21 January 2018

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Jak2 is essential for signaling through a variety of cytokine receptors

21 January 2018

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

1 reference

The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models

21 January 2018

1 reference

IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development

21 January 2018

1 reference

Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3.

21 January 2018

1 reference

Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation

21 January 2018

1 reference

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

21 January 2018

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Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

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Control of Leishmania major in the absence of Tyk2 kinase.

21 January 2018

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The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses

21 January 2018

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

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A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.

21 January 2018

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A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.

21 January 2018

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A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

21 January 2018

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Components of a Stat recognition code: evidence for two layers of molecular selectivity

21 January 2018

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The STATs of cancer--new molecular targets come of age

21 January 2018

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Transcription factors as targets for cancer therapy

21 January 2018

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

21 January 2018

1 reference

The biology of Stat4 and Stat6

21 January 2018

1 reference

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis

21 January 2018

1 reference

Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy

21 January 2018

1 reference

Mechanistic insights into impaired dendritic cell function by rapamycin: inhibition of Jak2/Stat4 signaling pathway

21 January 2018

1 reference

Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes

21 January 2018

1 reference

Stats: transcriptional control and biological impact

21 January 2018

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Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency

21 January 2018

1 reference

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

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Inhibitors of cytokine signal transduction

21 January 2018

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Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling

21 January 2018

1 reference

Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

21 January 2018

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SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

21 January 2018

1 reference

Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts

21 January 2018

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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts

21 January 2018

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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells

21 January 2018

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Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

21 January 2018

1 reference

Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.

21 January 2018

1 reference

Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

21 January 2018

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IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.

21 January 2018

1 reference

PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection

21 January 2018

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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 January 2018

1 reference

Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine.

21 January 2018

1 reference

Naphthyl ketones: a new class of Janus kinase 3 inhibitors

21 January 2018

1 reference

Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99

21 January 2018

1 reference

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes

31 March 2020

1 reference

The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.

31 March 2020

1 reference

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

31 March 2020

1 reference

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

31 March 2020

1 reference

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

31 March 2020

1 reference

Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

31 March 2020

1 reference

Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways.

31 March 2020

1 reference

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

31 March 2020

1 reference

Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency

31 March 2020

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Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice

31 March 2020

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In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

31 March 2020

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Interleukin-2 signaling and the maintenance of self-tolerance

31 March 2020

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Genetic models of abnormal apoptosis in lymphocytes

31 March 2020

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Protein kinase C inhibitors as novel anticancer drugs

31 March 2020

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Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria

31 March 2020

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CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited

31 March 2020

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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

31 March 2020

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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells

31 March 2020

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The use of antibodies against the IL-2 receptor in transplantation

31 March 2020

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Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

31 March 2020

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Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells

31 March 2020

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Immune response in Stat2 knockout mice

31 March 2020

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Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice

31 March 2020

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Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor

31 March 2020

1 reference

Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model

31 March 2020

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A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1441

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Dimensions Publication ID

10 August 2017

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