(Q35719387)

26218133

9 August 2017

title

Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity (English)

1 reference

9 August 2017

0 references

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1

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15 June 2020

Chin-Chaun Chen

7

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15 June 2020

author name string

Pei-Ya Lin

2

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15 June 2020

Ya-Chen Chiu

3

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15 June 2020

Ju-Sui Huang

4

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15 June 2020

Yi-Tsen Kuo

5

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15 June 2020

Jen-Chine Wu

6

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15 June 2020

language of work or name

English

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publication date

28 July 2015

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9 August 2017

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15 June 2020

volume

10

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15 June 2020

issue

7

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15 June 2020

page(s)

e0134110

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Creative Commons Attribution 4.0 International

15 June 2020

copyright license

start time

28 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

27 July 2018

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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

27 July 2018

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Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae

27 July 2018

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Molecular mechanisms of curcumin action: signal transduction

27 July 2018

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Targeting DNA repair mechanisms in cancer

27 July 2018

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Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement

27 July 2018

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Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

27 July 2018

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Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells

27 July 2018

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Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells

27 July 2018

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Epigenetic changes induced by curcumin and other natural compounds.

27 July 2018

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Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

27 July 2018

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27 July 2018

DNA damage and autophagy

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HDACs link the DNA damage response, processing of double-strand breaks and autophagy

27 July 2018

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Who's who in human recombination: BRCA2 and RAD52.

27 July 2018

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DNA repair targeting and radiotherapy: a focus on the therapeutic ratio

27 July 2018

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Targeting DNA damage and repair by curcumin

27 July 2018

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Rad52 SUMOylation affects the efficiency of the DNA repair

27 July 2018

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Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells

27 July 2018

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Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal

27 July 2018

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Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation

27 July 2018

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The emerging role of nuclear architecture in DNA repair and genome maintenance

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast

27 July 2018

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Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line

27 July 2018

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Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells

27 July 2018

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Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.

27 July 2018

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Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.

27 July 2018

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

27 July 2018

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Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

27 July 2018

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27 July 2018

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Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair

27 July 2018

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Molecular anatomy of the DNA damage and replication checkpoints

27 July 2018

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Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway

27 July 2018

1 reference

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Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

NuA4 subunit Yng2 function in intra-S-phase DNA damage response

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

A unified view of the DNA-damage checkpoint

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Effects of controlled RAD52 expression on repair and recombination in Saccharomyces cerevisiae

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18)

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4517890

10.1371/JOURNAL.PONE.0134110

25 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26218133%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26218133%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

26218133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26218133%20AND%20SRC:MED&resulttype=core&format=json