(Q38072888)

28 August 2017

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title

Molecular mechanisms of curcumin action: signal transduction (English)

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28 August 2017

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Adeeb Shehzad

1

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28 August 2017

Young Sup Lee

series ordinal

2

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28 August 2017

publication date

10 January 2013

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28 August 2017

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28 August 2017

volume

39

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28 August 2017

issue

1

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28 August 2017

page(s)

27-36

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Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin

28 August 2017

cites work

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Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?

21 January 2018

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Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs

21 January 2018

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Curcumin and cancer: an "old-age" disease with an "age-old" solution

21 January 2018

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Curcumin: from ancient medicine to current clinical trials.

21 January 2018

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Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials

21 January 2018

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Multitargeting by curcumin as revealed by molecular interaction studies

21 January 2018

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Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL).

21 January 2018

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Endoplasmic reticulum stress signaling in disease

21 January 2018

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Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

21 January 2018

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DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway

21 January 2018

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Curcumin-induced apoptosis in human hepatocellular carcinoma j5 cells: critical role of ca(+2)-dependent pathway

21 January 2018

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Targeting sarcoplasmic/endoplasmic reticulum Ca²+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma

21 January 2018

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Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

21 January 2018

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Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

21 January 2018

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Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).

21 January 2018

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Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human

21 January 2018

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Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway

21 January 2018

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Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis

21 January 2018

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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

21 January 2018

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Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells

21 January 2018

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Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases

21 January 2018

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

21 January 2018

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The p53 pathway: positive and negative feedback loops

21 January 2018

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Curcumin impairs tumor suppressor p53 function in colon cancer cells

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

21 January 2018

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Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells

21 January 2018

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Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin

21 January 2018

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Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

21 January 2018

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Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells

21 January 2018

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Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression

21 January 2018

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Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells

21 January 2018

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21 January 2018

Signaling to NF-kappaB

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Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

21 January 2018

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Anti-inflammatory mechanism of 15,16-epoxy-3α-hydroxylabda-8,13(16),14-trien-7-one via inhibition of LPS-induced multicellular signaling pathways.

21 January 2018

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Signal transduction events elicited by cancer prevention compounds

21 January 2018

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Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation

21 January 2018

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Curcumin attenuates DNB-induced murine colitis.

21 January 2018

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Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway.

21 January 2018

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Curcumin therapeutic promises and bioavailability in colorectal cancer

21 January 2018

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p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis

21 January 2018

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Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

21 January 2018

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Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells

21 January 2018

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Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

21 January 2018

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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibi

21 January 2018

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Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute lymphoblastic leukemia

21 January 2018

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Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

21 January 2018

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Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-κB signaling pathways

21 January 2018

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Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer.

21 January 2018

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Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling

21 January 2018

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Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling

21 January 2018

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Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

21 January 2018

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Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

21 January 2018

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Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets

21 January 2018

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New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

21 January 2018

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Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats

21 January 2018

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Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice

21 January 2018

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Wnt signaling in osteoblasts and bone diseases

21 January 2018

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Wnt/β-catenin/LEF-1 signaling in chronic lymphocytic leukemia (CLL): a target for current and potential therapeutic options

21 January 2018

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

21 January 2018

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Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling.

21 January 2018

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Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.

21 January 2018

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JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures

21 January 2018

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Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

21 January 2018

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SOCS proteins: negative regulators of cytokine signaling

21 January 2018

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JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells

21 January 2018

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Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia

21 January 2018

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Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.

21 January 2018

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The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.

21 January 2018

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Function of mitochondrial Stat3 in cellular respiration

21 January 2018

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Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury

21 January 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

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AMP-activated protein kinase, stress responses and cardiovascular diseases

21 January 2018

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Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.

21 January 2018

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AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

21 January 2018

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HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation

21 January 2018

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Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells

21 January 2018

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Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice

21 January 2018

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Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin

21 January 2018

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Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells.

21 January 2018

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Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis

21 January 2018

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Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

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Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.1065

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28 August 2017

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