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Trisomy 21 and early brain development
scientific article published on 9 December 2011
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Europe PubMed Central
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3273608
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18 January 2020
title
Trisomy 21 and early brain development
(English)
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Europe PubMed Central
PMC publication ID
3273608
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
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18 January 2020
author
Tarik F Haydar
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1
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Europe PubMed Central
PMC publication ID
3273608
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
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18 January 2020
author name string
Roger H Reeves
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2
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Europe PubMed Central
PMC publication ID
3273608
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18 January 2020
publication date
9 December 2011
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Europe PubMed Central
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3273608
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retrieved
18 January 2020
published in
Trends in Neurosciences
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3273608
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18 January 2020
volume
35
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18 January 2020
issue
2
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Europe PubMed Central
PMC publication ID
3273608
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
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18 January 2020
page(s)
81-91
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Europe PubMed Central
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3273608
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18 January 2020
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Behavioral phenotype of individuals with Down syndrome
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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
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Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"
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A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region
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27 July 2018
Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition
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27 July 2018
Cogeneration of retrogradely labeled corticocortical projection and GABA-immunoreactive local circuit neurons in cerebral cortex
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27 July 2018
Dendritic atrophy in children with Down's syndrome
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Postnatal delay of myelin formation in brains from Down syndrome infants and children.
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27 July 2018
Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months.
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27 July 2018
The gastrointestinal tract in Down syndrome
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27 July 2018
Magnetic resonance imaging evaluation of delayed myelination in Down syndrome: a case report and review of the literature
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27 July 2018
Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
27 July 2018
An assessment of the vestibulo-ocular reflex (VOR) in persons with Down syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
MNB/DYRK1A as a multiple regulator of neuronal development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Role of the cerebellar cortex in conditioned goal-directed behavior.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of [...]
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Human cortical neurons originate from radial glia and neuron-restricted progenitors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
The temporal and spatial origins of cortical interneurons predict their physiological subtype.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
On dendrites in Down syndrome and DS murine models: a spiny way to learn.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
A chromosome 21 critical region does not cause specific Down syndrome phenotypes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Motor learning in Ts65Dn mice, a model for Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Motor dysfunction in a mouse model for Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Origin and route of tangentially migrating neurons in the developing neocortical intermediate zone.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Cerebellar volume in adults with Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Dynamics of cell migration from the lateral ganglionic eminence in the rat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Glutamate, GABA and epilepsy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Synaptic development in the human fetus: a morphometric analysis of normal and Down's syndrome neocortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
The hippocampus in Down's syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Times of generation of glutamic acid decarboxylase immunoreactive neurons in mouse somatosensory cortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Dendrites, dementia and the Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Anomalous brain morphology on magnetic resonance images in Williams syndrome and Down syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273608
retrieved
25 September 2018
Cephalometric comparison between children with and without Down's syndrome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Replication rate and lifespan of cultured fibroblasts in Down's syndrome
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Craniofacial complex in the trisomy 21 syndrome (Down's syndrome)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Congenital cardiovascular malformations associated with chromosome abnormalities: an epidemiologic study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22169531
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TINS.2011.11.001
1 reference
stated in
Europe PubMed Central
PMC publication ID
3273608
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
PMC publication ID
3273608
1 reference
stated in
Europe PubMed Central
PMC publication ID
3273608
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
PubMed publication ID
22169531
1 reference
stated in
Europe PubMed Central
PMC publication ID
3273608
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22169531%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 January 2020
ResearchGate publication ID
51878350
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