(Q35744520)

10 August 2017

title

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export (English)

1 reference

10 August 2017

Balaji Manicassamy

4

0 references

Christian V Forst

Christian V Forst

9

0 references

Michael G. Roth

Michael G Roth

10

0 references

David E. Levy

David E Levy

11

0 references

Adolfo García-Sastre

Adolfo García-Sastre

12

0 references

Margaret A. Phillips

14

Margaret A Phillips

1 reference

10 August 2017

3

Mirco Schmolke

1 reference

10 August 2017

Liang Zhang

1

1 reference

10 August 2017

Priyabrata Das

2

1 reference

10 August 2017

Yaming Wang

5

1 reference

10 August 2017

Xiaoyi Deng

6

1 reference

10 August 2017

Ling Cai

7

1 reference

10 August 2017

Benjamin P Tu

8

1 reference

10 August 2017

Jef de Brabander

13

1 reference

10 August 2017

Beatriz M A Fontoura

15

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 February 2012

1 reference

10 August 2017

published in

Journal of Cell Biology

1 reference

10 August 2017

volume

196

1 reference

10 August 2017

issue

3

1 reference

10 August 2017

page(s)

315-326

1 reference

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

10 August 2017

cites work

1 reference

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Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

12 July 2018

1 reference

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Characterization of dengue virus resistance to brequinar in cell culture

12 July 2018

1 reference

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Cellular networks involved in the influenza virus life cycle

12 July 2018

1 reference

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Viral tricks to grid-lock the type I interferon system

12 July 2018

1 reference

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Features and development of Coot

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Response network analysis of differential gene expression in human epithelial lung cells during avian influenza infections

12 July 2018

1 reference

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Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

12 July 2018

1 reference

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Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

12 July 2018

1 reference

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A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Human host factors required for influenza virus replication

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Leflunomide inhibition of BK virus replication in renal tubular epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Human Protein Reference Database--2009 update

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Hypoxia inducible factor (HIF) function in innate immunity and infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Systematic Discovery of In Vivo Phosphorylation Networks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza virus targets the mRNA export machinery and the nuclear pore complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

IntAct--open source resource for molecular interaction data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Nuclear export assays for poly(A) RNAs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Differential network expression during drug and stress response.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The CCP4 suite: programs for protein crystallography

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

UCSF Chimera--a visualization system for exploratory research and analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Mapping the antigenic and genetic evolution of influenza virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

New drugs for rheumatoid arthritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Defective translational control facilitates vesicular stomatitis virus oncolysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Role of nucleoporin induction in releasing an mRNA nuclear export block

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Functional classification of interferon-stimulated genes identified using microarrays

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Inhibition of Ran guanosine triphosphatase-dependent nuclear transport by the matrix protein of vesicular stomatitis virus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

A geometric approach to macromolecule-ligand interactions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3275370

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

12 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201107058

Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201107058

A mutant of Sindbis virus that is resistant to pyrazofurin encodes an altered RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201107058

Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201107058

Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201107058

Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide

21 January 2018

1 reference

12 December 2020

Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium

1 reference

12 December 2020

Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis

1 reference

12 December 2020

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

1 reference

12 December 2020

In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients

1 reference

12 December 2020

PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.201107058

1 reference

10 August 2017

1 reference

10 August 2017

1 reference