(Q35750741)

10 August 2017

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title

Deciphering enzymes. Genetic selection as a probe of structure and mechanism (English)

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10 August 2017

author name string

Kenneth J Woycechowsky

series ordinal

1

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10 August 2017

Donald Hilvert

series ordinal

2

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

volume

271

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10 August 2017

issue

9

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10 August 2017

page(s)

1630-1637

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The depth of chemical time and the power of enzymes as catalysts.

10 August 2017

cites work

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Enzymes for chemical synthesis

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Industrial biocatalysis today and tomorrow

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De novo design and structural characterization of proteins and metalloproteins

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Investigating and Engineering Enzymes by Genetic Selection

21 January 2018

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3D structural information as a guide to protein engineering using genetic selection

21 January 2018

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Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis

21 January 2018

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A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii

21 January 2018

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Searching sequence space for protein catalysts

21 January 2018

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21 January 2018

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The role of turns in the structure of an alpha-helical protein.

21 January 2018

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Redesigning enzyme topology by directed evolution

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Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor

21 January 2018

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Apparent NAC effect in chorismate mutase reflects electrostatic transition state stabilization

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Understanding the Role of Active‐Site Residues in Chorismate Mutase Catalysis from Molecular‐Dynamics Simulations

21 January 2018

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Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes, and their mutants).

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A strategically positioned cation is crucial for efficient catalysis by chorismate mutase

21 January 2018

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Transition state stabilization and substrate strain in enzyme catalysis: ab initio QM/MM modelling of the chorismate mutase reaction.

21 January 2018

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Probing the role of the C-terminus of Bacillus subtilis chorismate mutase by a novel random protein-termination strategy

21 January 2018

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Reverse engineering the (beta/alpha )8 barrel fold

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Stability, catalytic versatility and evolution of the (beta alpha)(8)-barrel fold.

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De novo backbone and sequence design of an idealized alpha/beta-barrel protein: evidence of stable tertiary structure

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Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily

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Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

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Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways

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Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I.

21 January 2018

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High-throughput screening of enzyme libraries

21 January 2018

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Combinatorial and computational challenges for biocatalyst design

21 January 2018

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Computational design of receptor and sensor proteins with novel functions

21 January 2018

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Alternative packing arrangements in the hydrophobic core of λrepresser

21 January 2018

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The Lesser “Burden Borne” byo-Succinylbenzoate Synthase: An “Easy” Reaction Involving a Carboxylate Carbon Acid

21 January 2018

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21 January 2018

Identifiers

DOI

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10 August 2017

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