(Q34150464)

31 July 2017

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title

Combinatorial and computational challenges for biocatalyst design (English)

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31 July 2017

Arnold FH

1

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31 July 2017

language of work or name

English

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publication date

1 January 2001

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31 July 2017

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31 July 2017

volume

409

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31 July 2017

issue

6817

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31 July 2017

page(s)

253-257

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https://scigraph.springernature.com/pub.10.1038/35051731

31 July 2017

exact match

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cites work

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Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

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Directed evolution of the surface chemistry of the reporter enzyme beta-glucuronidase

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Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude

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Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template

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Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids

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Exploring the possibilities presented by protein engineering

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DESATURATION AND RELATED MODIFICATIONS OF FATTY ACIDS1

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7 January 2021

Temperature adaptation of enzymes: lessons from laboratory evolution

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Stability and stabilization of globular proteins in solution

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7 January 2021

De novo protein design: fully automated sequence selection

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7 January 2021

Design, structure and stability of a hyperthermophilic protein variant

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7 January 2021

Tailoring new enzyme functions by rational redesign

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Directed evolution of an enantioselective lipase

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7 January 2021

Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine

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7 January 2021

Redesigning the substrate specificity of an enzyme by cumulative effects of the mutations of non-active site residues

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7 January 2021

Directed evolution of an aspartate aminotransferase with new substrate specificities

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7 January 2021

Structural analysis of affinity matured antibodies and laboratory-evolved enzymes

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7 January 2021

Rapid evolution of a protein in vitro by DNA shuffling

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7 January 2021

DNA shuffling of a family of genes from diverse species accelerates directed evolution

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7 January 2021

The biotechnological potential and design of novel carotenoids by gene combination in Escherichia coli

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Harnessing the biosynthetic code: combinations, permutations, and mutations

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7 January 2021

Molecular breeding of carotenoid biosynthetic pathways

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The immunological evolution of catalysis

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7 January 2021

From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins.

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7 January 2021

Evolution of protein function by domain swapping

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7 January 2021

Libraries of hybrid proteins from distantly related sequences

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7 January 2021

Novel folded protein domains generated by combinatorial shuffling of polypeptide segments

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In vitro selection and evolution of proteins

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7 January 2021

Totally in vitro protein selection using mRNA-protein fusions and ribosome display

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High-throughput screening of enzyme libraries

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Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold

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Computational method to reduce the search space for directed protein evolution

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Rational design of nascent metalloenzymes

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7 January 2021

Identifiers

DOI

10.1038/35051731

1 reference

Dimensions Publication ID

31 July 2017

1051677107

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