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MDA5-filament, dynamics and disease
scientific article published on 9 February 2015
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scholarly article
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Europe PubMed Central
PubMed publication ID
25676875
retrieved
10 August 2017
review article
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Europe PubMed Central
title
MDA5-filament, dynamics and disease
(English)
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stated in
Europe PubMed Central
PubMed publication ID
25676875
retrieved
10 August 2017
author
Bin Wu
series ordinal
2
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stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
author name string
Yoandris del Toro Duany
series ordinal
1
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stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
Sun Hur
series ordinal
3
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stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
publication date
9 February 2015
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stated in
Europe PubMed Central
PubMed publication ID
25676875
retrieved
10 August 2017
published in
Current opinion in virology
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stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
volume
12
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Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
page(s)
20-25
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Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
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MDA5 localizes to stress granules, but this localization is not required for the induction of type I interferon
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Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production
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2 October 2017
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5
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2 October 2017
Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity
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2 October 2017
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA
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Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity
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Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
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2 October 2017
Structural Insights into RNA Recognition by RIG-I
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2 October 2017
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
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MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
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Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2
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2 October 2017
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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
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2 October 2017
Motoring along with the bacterial RecA protein
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2 October 2017
5'-Triphosphate RNA is the ligand for RIG-I
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4470736
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2 October 2017
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4470736
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2 October 2017
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
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2 October 2017
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
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2 October 2017
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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2 October 2017
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
1 reference
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2 October 2017
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
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2 October 2017
Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation
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2 October 2017
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
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2 October 2017
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
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12 July 2018
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.
1 reference
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PubMed Central
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12 July 2018
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4470736
retrieved
12 July 2018
Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4470736
retrieved
25 September 2018
Statistical false positive or true disease pathway?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4470736
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23 October 2018
Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25676875
retrieved
12 December 2020
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Identifiers
DOI
10.1016/J.COVIRO.2015.01.011
1 reference
stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PMC publication ID
4470736
1 reference
stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
PubMed publication ID
25676875
1 reference
stated in
Europe PubMed Central
PMC publication ID
4470736
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25676875%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 June 2020
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