(Q35752873)

English

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation

scientific article published on 23 February 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

toll-like receptor

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1 reference

based on heuristic

inferred from title

Erwin Tschachler

8

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

4

object named as

Philipp Starkl

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Erika Jensen-Jarolim

10

object named as

Erika Jensen-Jarolim

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Michael Mildner

object named as

Michael Mildner

7

0 references

author name string

Caroline Stremnitzer

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Krisztina Manzano-Szalai

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Anna Willensdorfer

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Mario Pieper

5

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Peter König

6

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Ursula Reichart

9

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

0 references

publication date

23 February 2015

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Journal of Investigative Dermatology

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

135

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1790-1800

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Epicutaneous immunity and onset of allergic diseases - per-"eczema"tous sensitization drives the allergy march

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Enzymes in cleaning products: an overview of toxicological properties and risk assessment/management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

The airway epithelium in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Relevance of sensitization to occupational allergy and asthma in the detergent industry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Development of enteric submicron particle formulation of papain for oral delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Role of the epidermal barrier in atopic dermatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Comparative enzymology of native and recombinant house dust mite allergen Der p 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Animal models of atopic dermatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

The skin: an indispensable barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Enzymatic wound debridement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

A mechanism for the initiation of allergen-induced T helper type 2 responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

The role of protease activation of inflammation in allergic respiratory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Multiple IgE-mediated sensitizations to enzymes after occupational exposure: evaluation by skin prick test, RAST, and immunoblot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Systemic reaction to papain in a nonoccupational setting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

Crystal structure of a papain-E-64 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

2 October 2017

High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

12 July 2018

Biochemical and immunological characterization of a recombinant precursor form of the house dust mite allergen Der p 1 produced by Drosophila cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

12 July 2018

ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Tight junctions form a barrier in human epidermis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Digestive enzyme supplementation for autism spectrum disorders: a double-blind randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Even-numbered peptides from a papain hydrolysate of silk fibroin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Protease supplementation improves muscle function after eccentric exercise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

The enzyme papain in industry and food causes allergic sensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Kiwellin, a modular protein from green and gold kiwi fruits: evidence of in vivo and in vitro processing and IgE binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Human eosinophils are activated by cysteine proteases and release inflammatory mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Enzymatically active papain preferentially induces an allergic response in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

25 September 2018

Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4471117

15 November 2018

[Papain-induced allergy in a cosmetician]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative delivery efficiency and convenience of spray and ointment formulations of papain/urea/chlorophyllin enzymatic wound therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tight junctions and tight junction proteins in mammalian epidermis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of protease supplementation on skeletal muscle function and DOMS following downhill running

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Occupational allergies to papain]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epicutaneous sensitization with a protein antigen induces Th17 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated epicutaneous exposures to ovalbumin progressively induce atopic dermatitis-like skin lesions in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epicutaneous sensitization with protein antigen induces Th9 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitizing and Th2 adjuvant activity of cysteine protease allergens

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgE-mediated allergy to bromelain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCL8 and skin T cells--an allergic attraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allergy to latex and papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contact urticaria from papain in a soft lens solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local ocular anaphylaxis to papain enzyme contained in a contact lens cleansing solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Papain-induced allergic rhinoconjunctivitis in a cosmetologist

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalized drug reaction due to papaya juice in throat lozenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytically active allergens cause barrier breakdown

1 reference

https://pubmed.ncbi.nlm.nih.gov/25705851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/JID.2015.58

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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