(Q35753046)

10 August 2017

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title

Molecular biology of gliomas (English)

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10 August 2017

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Andrew B Lassman

1

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10 August 2017

publication date

1 May 2004

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Current Neurology and Neuroscience Reports

10 August 2017

published in

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10 August 2017

volume

4

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10 August 2017

issue

3

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10 August 2017

page(s)

228-233

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Regulation of p53 function and stability by phosphorylation

10 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS11910-004-0043-3

Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS11910-004-0043-3

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

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12 December 2020

Amplification of a gene encoding a p53-associated protein in human sarcomas

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12 December 2020

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

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12 December 2020

Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.

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12 December 2020

Oncogenic kinase signalling

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12 December 2020

Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2

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12 December 2020

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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12 December 2020

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.

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12 December 2020

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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12 December 2020

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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12 December 2020

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

EGF mutant receptor vIII as a molecular target in cancer therapy

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12 December 2020

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

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12 December 2020

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

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12 December 2020

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

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12 December 2020

The treatment of glioblastoma multiforme.

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12 December 2020

The E2F transcription factor is a cellular target for the RB protein

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12 December 2020

Amplification and differential expression of members of the erbB-gene family in human glioblastoma.

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12 December 2020

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

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12 December 2020

Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway

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12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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12 December 2020

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

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12 December 2020

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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12 December 2020

G1 events and regulation of cell proliferation

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12 December 2020

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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12 December 2020

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

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12 December 2020

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines

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12 December 2020

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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12 December 2020

TOR, a central controller of cell growth

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12 December 2020

Proliferation of human malignant astrocytomas is dependent on Ras activation

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12 December 2020

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

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12 December 2020

Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.

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12 December 2020

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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12 December 2020

Primary and secondary glioblastomas: from concept to clinical diagnosis

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12 December 2020

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

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12 December 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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12 December 2020

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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12 December 2020

Platelet-derived growth factor and its receptor expression in human oligodendrogliomas

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12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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12 December 2020

MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme.

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12 December 2020

Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

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12 December 2020

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas

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12 December 2020

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

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12 December 2020

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12 December 2020

10.1007/S11910-004-0043-3

Identifiers

DOI

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10 August 2017

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