(Q52540552)

3 May 2018

title

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. (English)

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3 May 2018

author

Monika E Hegi

6

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3 May 2018

Erwin G. Van Meir

9

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3 May 2018

author name string

G Fulci

1

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3 May 2018

M Labuhn

2

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3 May 2018

D Maier

3

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3 May 2018

Y Lachat

4

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3 May 2018

O Hausmann

5

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3 May 2018

R C Janzer

7

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3 May 2018

A Merlo

8

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3 May 2018

language of work or name

English

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publication date

1 August 2000

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3 May 2018

published in

Oncogene

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3 May 2018

volume

19

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3 May 2018

page(s)

3816-3822

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3 May 2018

issue

33

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3 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1203700

exact match

0 references

cites work

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PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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PTEN mutations in gliomas and glioneuronal tumors.

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The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies

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p53 and brain tumors: from gene mutations to gene therapy

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme.

21 January 2018

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Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.

21 January 2018

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice.

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

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DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours

21 January 2018

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Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

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Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

21 January 2018

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7 January 2021

Reliability of differential PCR for the detection of EGFR and MDM2 gene amplification in DNA extracted from FFPE glioma tissue.

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7 January 2021

Type and frequency of p53 mutations in tumors of the nervous system and its coverings.

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7 January 2021

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer

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7 January 2021

Expression of p16INK4a/p16alpha and p19ARF/p16beta is frequently altered in non-small cell lung cancer and correlates with p53 overexpression

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203700

1 reference

3 May 2018

PubMed ID

10949938

1 reference

3 May 2018