(Q45889835)

17 December 2017

review article

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title

p53 and brain tumors: from gene mutations to gene therapy (English)

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17 December 2017

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3

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17 December 2017

author name string

G Fulci

series ordinal

1

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17 December 2017

N Ishii

series ordinal

2

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17 December 2017

publication date

1 October 1998

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17 December 2017

published in

Brain Pathology

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17 December 2017

volume

8

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17 December 2017

page(s)

599-613

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17 December 2017

issue

4

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17 December 2017

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes

21 January 2018

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21 January 2018

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Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

21 January 2018

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The p53 gene and its role in human brain tumors.

21 January 2018

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Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes.

21 January 2018

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

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Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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A p53-dependent mouse spindle checkpoint

21 January 2018

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Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

21 January 2018

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

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Gain of function mutations in p53.

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Retroviral-mediated transduction of p53 gene increases TGF-beta expression in a human glioblastoma cell line

21 January 2018

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Abnormal centrosome amplification in the absence of p53.

21 January 2018

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p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma

21 January 2018

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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

21 January 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

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Timing and role of p53 gene mutation in the recurrence of glioma.

21 January 2018

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Establishment of spontaneously immortalized rat type 1 astroglial cell lines: the role of p53 in astroglial carcinogenesis

21 January 2018

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Transformation of type 1 astrocytes with N-ethyl-N-nitrosourea: establishment of an in vitro system and the role of the p53 gene

21 January 2018

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Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

21 January 2018

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Functional expression of human p21(WAF1/CIP1) gene in rat glioma cells suppresses tumor growth in vivo and induces radiosensitivity.

21 January 2018

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Intracavitary liposome-mediated p53 gene transfer into glioblastoma with endogenous wild-type p53 in vivo results in tumor suppression and long-term survival

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Genetic and environmental factors in the etiology of human brain tumors

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Multifocal cerebral gliomas associated with secondary malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity

21 January 2018

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Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Inactivation of p53 results in high rates of homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Prognostic factors in malignant glioma: influence of the overexpression of oncogene and tumor-suppressor gene products on survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Clonal expansion of p53 mutant cells is associated with brain tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Clonality and stability of the p53 gene in human astrocytic tumor cells: quantitative analysis of p53 gene mutations by yeast functional assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Absence of mutations and identification of two polymorphisms in the SSCP and sequence analysis of p21CKI gene in malignant gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Subsets of glioblastoma multiforme defined by molecular genetic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

p53 modulation of TFIIH-associated nucleotide excision repair activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

p53 expression and prognosis in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1750-3639.1998.TB00187.X

10.1111/J.1750-3639.1998.TB00187.X

21 January 2018

Identifiers

DOI

1 reference

17 December 2017

PubMed ID

9804370

1 reference

17 December 2017