(Q35762636)

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Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase

scientific article published on 5 April 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Soluble epoxide hydrolase

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4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

author name string

Sung Hee Hwang

1

1 reference

Europe PubMed Central

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26 January 2020

Karen M Wagner

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Christophe Morisseau

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Hua Dong

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Aaron T Wecksler

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Bruce D Hammock

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

language of work or name

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publication date

5 April 2011

1 reference

Europe PubMed Central

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26 January 2020

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

54

1 reference

Europe PubMed Central

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26 January 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

3037-3050

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension

1 reference

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2 October 2017

Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events.

1 reference

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2 October 2017

Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression

1 reference

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2 October 2017

Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury

1 reference

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2 October 2017

Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches

1 reference

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2 October 2017

Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery

1 reference

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2 October 2017

Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis

1 reference

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2 October 2017

Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond

1 reference

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2 October 2017

Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation

1 reference

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2 October 2017

Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

1 reference

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2 October 2017

Cyclooxygenases: structural and functional insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281519

2 October 2017

Celecoxib inhibits 5-lipoxygenase

1 reference

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2 October 2017

Orally bioavailable potent soluble epoxide hydrolase inhibitors

1 reference

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2 October 2017

The trouble with making combination drugs

1 reference

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2 October 2017

Action of epoxyeicosatrienoic acids on cellular function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281519

2 October 2017

Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors

1 reference

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2 October 2017

Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors

1 reference

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2 October 2017

Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases

1 reference

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2 October 2017

Designed multiple ligands. An emerging drug discovery paradigm

1 reference

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2 October 2017

New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy

1 reference

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2 October 2017

Coxibs and cardiovascular disease

1 reference

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2 October 2017

From magic bullets to designed multiple ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281519

2 October 2017

Recent development in the field of dual COX / 5-LOX inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281519

2 October 2017

Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281519

2 October 2017

Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer

1 reference

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2 October 2017

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

1 reference

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2 October 2017

Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs

1 reference

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2 October 2017

Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors

1 reference

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2 October 2017

Understanding NSAIDs: from aspirin to COX-2

1 reference

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2 October 2017

Cyclooxygenase inhibitors--current status and future prospects

1 reference

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2 October 2017

Cyclooxygenase-2 inhibition and side-effects of non-steroidal anti-inflammatory drugs in the gastrointestinal tract

1 reference

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2 October 2017

Selective inhibitors of cyclooxygenase-2 (COX-2).

1 reference

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2 October 2017

New role for epoxyeicosatrienoic acids as anti-inflammatory mediators

1 reference

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2 October 2017

Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase

1 reference

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2 October 2017

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

1 reference

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2 October 2017

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

1 reference

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2 October 2017

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor

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12 December 2020

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inferred from PubMed ID database lookup

Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The physicochemical challenges of designing multiple ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21434686

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21434686

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent

1 reference

https://pubmed.ncbi.nlm.nih.gov/21434686

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM2001376

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21434686%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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