(Q35763278)

English

Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent

scientific article published on 2 November 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 August 2017

Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent (English)

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PubMed publication ID

10 August 2017

Behzad Javaheri

4

object named as

Behzad Javaheri

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Europe PubMed Central

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10 August 2017

Gabriel L Galea

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author name string

Gul Zaman

1

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10 August 2017

Andrew Sunters

2

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10 August 2017

Gabriel L Galea

3

1 reference

Europe PubMed Central

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10 August 2017

Leanne K Saxon

5

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10 August 2017

Alaa Moustafa

6

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Europe PubMed Central

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10 August 2017

Victoria J Armstrong

7

1 reference

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10 August 2017

Joanna S Price

8

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10 August 2017

Lance E Lanyon

9

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10 August 2017

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publication date

2 November 2011

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10 August 2017

Journal of Biological Chemistry

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10 August 2017

287

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10 August 2017

6

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Europe PubMed Central

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10 August 2017

3946-3962

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Europe PubMed Central

PubMed publication ID

10 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3281728/fullTextXML

based on heuristic

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Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

1 reference

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Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice

1 reference

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Gene expression patterns in bone following mechanical loading

1 reference

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1 reference

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Antagonistic interplay between mechanical forces and glucocorticoids in bone: a tale of kinases

1 reference

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Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells.

1 reference

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Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse

1 reference

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2 October 2017

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

1 reference

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2 October 2017

The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

1 reference

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Promiscuous and depolarization-induced immediate-early response genes are induced by mechanical strain of osteoblasts

1 reference

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

1 reference

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2 October 2017

Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures.

1 reference

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Molecular and cellular mechanisms of the anabolic effect of intermittent PTH

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Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha

1 reference

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2 October 2017

Wnt signaling: a key regulator of bone mass

1 reference

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2 October 2017

Osteocytes use estrogen receptor alpha to respond to strain but their ERalpha content is regulated by estrogen

1 reference

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Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

1 reference

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Fluid shear stress synergizes with insulin-like growth factor-I (IGF-I) on osteoblast proliferation through integrin-dependent activation of IGF-I mitogenic signaling pathway.

1 reference

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Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer

1 reference

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2 October 2017

Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins

1 reference

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2 October 2017

krox-20/egr-2 is up-regulated following non-specific and homophilic adhesion in rat macrophages

1 reference

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2 October 2017

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways

1 reference

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2 October 2017

Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.

1 reference

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Ligand binding to integrins

1 reference

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Cell adhesion: old and new questions

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A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease

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Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I.

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Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

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Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies

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The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation.

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2 October 2017

Role of Krox-20 in endochondral bone formation

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Defective bone formation in Krox-20 mutant mice

1 reference

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Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

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1 reference

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27 July 2018

Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females

1 reference

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Mechanical strain activates estrogen response elements in bone cells

1 reference

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27 July 2018

The estrogen receptor's involvement in osteoblasts' adaptive response to mechanical strain

1 reference

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Additive effects of estrogen and mechanical stress on nitric oxide and prostaglandin E2 production by bone cells from osteoporotic donors

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Efficacy data on teriparatide (parathyroid hormone) in patients with postmenopausal osteoporosis.

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Establishment of hindbrain segmental identity requires signaling by FGF3 and FGF8.

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25 September 2018

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Effect of strain on bone nodule formation by rat osteogenic cells in vitro

1 reference

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Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen enhances the stimulation of bone collagen synthesis by loading and exogenous prostacyclin, but not prostaglandin E2, in organ cultures of rat ulnae

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parathyroid hormone restores bone mass and enhances osteoblast insulin-like growth factor I gene expression in ovariectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nitric oxide and prostaglandins in mechanically induced bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of prostaglandins and nitric oxide in the response of bone to mechanical forces

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading

1 reference

https://pubmed.ncbi.nlm.nih.gov/22049075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.252742

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

release_s5e5y65iu5erbnz4fuymm6ks2u

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https://api.fatcat.wiki/v0/release/s5e5y65iu5erbnz4fuymm6ks2u

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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