(Q35780797)

10 August 2017

1 reference

title

Vintafolide: a novel targeted therapy for the treatment of folate receptor expressing tumors (English)

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10 August 2017

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1

Ignace Vergote

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10 August 2017

Christopher P Leamon

2

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10 August 2017

publication date

1 July 2015

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Therapeutic advances in medical oncology

10 August 2017

published in

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10 August 2017

volume

7

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10 August 2017

issue

4

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10 August 2017

page(s)

206-218

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Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs

10 August 2017

cites work

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27 July 2018

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27 July 2018

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Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors

27 July 2018

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27 July 2018

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Multicenter trial of EC145 in advanced, folate-receptor positive adenocarcinoma of the lung

27 July 2018

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27 July 2018

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27 July 2018

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High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation

27 July 2018

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A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells

27 July 2018

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27 July 2018

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Farletuzumab, an anti-folate receptor α antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro

27 July 2018

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Role of farletuzumab in epithelial ovarian carcinoma

27 July 2018

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EC145: a novel targeted agent for adenocarcinoma of the lung

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers.

27 July 2018

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Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients

27 July 2018

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A history of cancer chemotherapy

27 July 2018

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Molecular mechanisms of adaptation to folate deficiency

27 July 2018

1 reference

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Folate receptor alpha as a tumor target in epithelial ovarian cancer

27 July 2018

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Preclinical antitumor activity of a novel folate-targeted dual drug conjugate

27 July 2018

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Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas

27 July 2018

1 reference

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Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.

27 July 2018

1 reference

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The folate receptor: what does it promise in tissue-targeted therapeutics?

27 July 2018

1 reference

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Comparing antibody and small-molecule therapies for cancer

27 July 2018

1 reference

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Role of folate receptor genes in reproduction and related cancers

27 July 2018

1 reference

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The realisation of targeted antitumour therapy

27 July 2018

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Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

27 July 2018

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Identification of two putative novel folate receptor genes in humans and mouse

27 July 2018

1 reference

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Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer

27 July 2018

1 reference

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Overexpression of folate binding protein in ovarian cancers.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

27 July 2018

1 reference

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Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity

27 July 2018

1 reference

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Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

27 July 2018

1 reference

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Receptor-mediated folate accumulation is regulated by the cellular folate content

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Phase II study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion SPECT-based imaging agent (99mTc-etarfolatide).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Folate receptor alpha (FRA) expression remains unchanged in epithelial ovarian and endometrial cancer after chemotherapy.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Clinical translation of folate receptor-targeted therapeutics

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Targeted cancer therapies in the twenty-first century: lessons from imatinib

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Rationale for folate receptor alpha targeted therapy in "high risk" endometrial carcinomas

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Folate receptor overexpression is associated with poor outcome in breast cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480526

Roadmap for the European Network of Gynaecological Trial groups (ENGOT) Trials

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177%2F1758834015584763

Degradation of BMS-753493, a novel epothilone folate conjugate anticancer agent

21 January 2018

1 reference

12 December 2020

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide

1 reference

12 December 2020

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity

1 reference

12 December 2020

Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer

1 reference

12 December 2020

The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer

1 reference

12 December 2020

PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer

1 reference

12 December 2020

Identifiers

DOI

10.1177/1758834015584763

1 reference

10 August 2017

1 reference

10 August 2017

1 reference