(Q35791186)

10 August 2017

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title

Nonviral DNA vectors for immunization and therapy: design and methods for their obtention (English)

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10 August 2017

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Ernesto G Rodríguez

1

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10 August 2017

publication date

3 June 2004

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Journal of Molecular Medicine

10 August 2017

published in

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10 August 2017

volume

82

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10 August 2017

issue

8

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10 August 2017

page(s)

500-509

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Side-chain-specific reactions to betalactams: 14 years later

10 August 2017

cites work

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12 December 2020

Latest development in viral vectors for gene therapy

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12 December 2020

New hope for an AIDS vaccine

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12 December 2020

A new DNA vehicle for nonviral gene delivery: supercoiled minicircle

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12 December 2020

DNA vaccines: immunology, application, and optimization*

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12 December 2020

Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya

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12 December 2020

Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial

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12 December 2020

Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine.

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12 December 2020

Immunostimulatory DNA sequences necessary for effective intradermal gene immunization

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12 December 2020

Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal

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12 December 2020

C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge

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12 December 2020

Technical issues in construction of nucleic acid vaccines

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12 December 2020

Plasmid DNA induces increased lymphocyte trafficking: a specific role for CpG motifs

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12 December 2020

DNA purification by triple-helix affinity precipitation

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12 December 2020

Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide

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12 December 2020

DNA vaccination with linear minimalistic (MIDGE) vectors confers protection against Leishmania major infection in mice.

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12 December 2020

pCOR: a new design of plasmid vectors for nonviral gene therapy

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12 December 2020

Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination

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12 December 2020

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

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12 December 2020

Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication

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12 December 2020

Design and tests of an HIV vaccine

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12 December 2020

Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus

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12 December 2020

Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device

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12 December 2020

A novel minimal-size vector (MIDGE) improves transgene expression in colon carcinoma cells and avoids transfection of undesired DNA.

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12 December 2020

Current status of DNA vaccines and their route of administration

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12 December 2020

Safety and immune responses to a DNA-based human immunodeficiency virus (HIV) type I env/rev vaccine in HIV-infected recipients: follow-up data

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12 December 2020

Key issues in non-viral gene delivery.

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12 December 2020

Genetic adjuvants for DNA vaccines

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12 December 2020

Production of supercoiled multimeric plasmid DNA for biopharmaceutical application

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12 December 2020

Technical and regulatory hurdles for DNA vaccines

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12 December 2020

Efficient purification of plasmid DNA for gene transfer using triple-helix affinity chromatography

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12 December 2020

Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline interleukin-12 (IL-12), IL-16, or a CpG motif

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12 December 2020

Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery

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12 December 2020

CpG motifs in bacterial DNA and their immune effects

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12 December 2020

DNA-based vaccination against hepatitis C virus (HCV): effect of expressing different forms of HCV E2 protein and use of CpG-optimized vectors in mice

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12 December 2020

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

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12 December 2020

Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines

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12 December 2020

Development of improved vectors for DNA-based immunization and other gene therapy applications

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12 December 2020

Strategies for improving the frequency and assessment of homologous recombination.

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12 December 2020

Genomic DNA released by dying cells induces the maturation of APCs

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12 December 2020

Transport of molecules in the tumor interstitium: a review

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12 December 2020

Simian immunodeficiency virus DNA vaccine trial in macaques.

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12 December 2020

Linear closed mini DNA generated by the prokaryotic cleaving-joining enzyme TelN is functional in mammalian cells.

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12 December 2020

An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy.

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12 December 2020

Enhanced cell-mediated IFN-gamma-secreting activity against the HIV-1IIIB V3 peptide of the TAB9 multiepitope after DNA vaccine backbone engineering

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12 December 2020

Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines

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12 December 2020

Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNA1: implications of the nuclear import of plasmids

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12 December 2020

Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo

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12 December 2020

Linear expression elements: a rapid, in vivo, method to screen for gene functions

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12 December 2020

Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers

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12 December 2020

CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes

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12 December 2020

The protelomerase of temperate Escherichia coli phage N15 has cleaving-joining activity

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12 December 2020

CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.

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12 December 2020

Heterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors.

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12 December 2020

Purification of plasmids for gene therapy and DNA vaccination.

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12 December 2020

Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine

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12 December 2020

Designing gene delivery vectors for cardiovascular gene therapy

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12 December 2020

Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle

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12 December 2020

A family of compact plasmid vectors for DNA immunization in humans

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12 December 2020

Sequence requirements for plasmid nuclear import

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12 December 2020

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

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12 December 2020

Analysis and use of endogenous nuclease activities in Escherichia coli lysates during the primary isolation of plasmids for gene therapy

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12 December 2020

A Direct and efficient synthesis method for dumbell-shaped linear DNA using PCR in vitro

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12 December 2020

Minicircle: an improved DNA molecule for in vitro and in vivo gene transfer

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12 December 2020

Catheter-based plasmid-mediated transfer of genes into ischemic myocardium using the pCOR plasmid

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12 December 2020

Main features of DNA-based immunization vectors

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12 December 2020

Replication and control of circular bacterial plasmids.

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12 December 2020

Cryptic open reading frames in plasmid vector backbone sequences can provide highly immunogenic cytotoxic T-lymphocyte epitopes

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12 December 2020

An improved plasmid DNA expression vector for direct injection into skeletal muscle

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12 December 2020

Repressor titration: a novel system for selection and stable maintenance of recombinant plasmids

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12 December 2020

CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses

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12 December 2020

Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA

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12 December 2020

High-yield production of pBR322-derived plasmids intended for human gene therapy by employing a temperature-controllable point mutation

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12 December 2020

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

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12 December 2020

High copy number of the pUC plasmid results from a Rom/Rop‐suppressible point mutation in RNA II

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12 December 2020

First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response

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12 December 2020

A regulated, NFkappaB-assisted import of plasmid DNA into mammalian cell nuclei

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12 December 2020

10.1007/S00109-004-0548-X

Identifiers

DOI

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10 August 2017

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