(Q35794568)

10 August 2017

title

Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila (English)

1 reference

10 August 2017

0 references

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Svetlana Trunova

1

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10 August 2017

Edward Giniger

series ordinal

2

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10 August 2017

language of work or name

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21 December 2011

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Disease Models & Mechanisms

10 August 2017

published in

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10 August 2017

volume

5

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10 August 2017

issue

2

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10 August 2017

page(s)

210-219

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Cdk5 regulates the size of an axon initial segment-like compartment in mushroom body neurons of the Drosophila central brain

10 August 2017

cites work

1 reference

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Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

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Molecular mechanisms of necroptosis: an ordered cellular explosion

27 July 2018

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Negative regulation of Vps34 by Cdk mediated phosphorylation

27 July 2018

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Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects

27 July 2018

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Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.

27 July 2018

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Autophagy takes flight in Drosophila

27 July 2018

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Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration

27 July 2018

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Autophagy, not apoptosis, is essential for midgut cell death in Drosophila

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Axonal injury and regeneration in the adult brain of Drosophila.

27 July 2018

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27 July 2018

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27 July 2018

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Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress

27 July 2018

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Autophagy is required for necrotic cell death in Caenorhabditis elegans.

27 July 2018

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Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan

27 July 2018

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Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein

27 July 2018

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Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila

27 July 2018

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Cyclin-dependent kinase-5 in neurodegeneration.

27 July 2018

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Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases

27 July 2018

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Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration

27 July 2018

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Cdk5: One of the links between senile plaques and neurofibrillary tangles?

27 July 2018

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Ultrastructure evidence of necrotic neural cell death in familial Alzheimer's disease brains bearing presenilin-1 E280A mutation

27 July 2018

1 reference

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The molecular bases of Alzheimer's disease and other neurodegenerative disorders

27 July 2018

1 reference

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NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

27 July 2018

1 reference

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Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis

27 July 2018

1 reference

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Fluorescent products and lysosomal components in aging Drosophila melanogaster

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Properties of the larval neuromuscular junction in Drosophila melanogaster

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Autophagy gone awry in neurodegenerative diseases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Development of the Drosophila mushroom bodies: sequential generation of three distinct types of neurons from a neuroblast.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3291642

15 November 2018

Identifiers

DOI

10.1242/DMM.008847

1 reference

10 August 2017

1 reference

10 August 2017

1 reference