(Q35804128)

English

Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation

scientific article published on March 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

based on heuristic

inferred from title

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object named as

Stephen Dalton

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Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Amar M Singh

1

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Europe PubMed Central

PMC publication ID

10 August 2017

David Reynolds

2

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Europe PubMed Central

PMC publication ID

10 August 2017

Timothy Cliff

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Satoshi Ohtsuka

4

1 reference

Europe PubMed Central

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10 August 2017

Alexa L Mattheyses

5

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Europe PubMed Central

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10 August 2017

Yuhua Sun

6

1 reference

Europe PubMed Central

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10 August 2017

Laura Menendez

7

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10 August 2017

Michael Kulik

8

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10 August 2017

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publication date

1 March 2012

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Europe PubMed Central

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10 August 2017

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Europe PubMed Central

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10 August 2017

10

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Europe PubMed Central

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10 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

312-326

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Concise review: A chemical approach to control cell fate and function

1 reference

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27 July 2018

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

1 reference

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27 July 2018

Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation

1 reference

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27 July 2018

Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

1 reference

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27 July 2018

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells.

1 reference

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27 July 2018

Pluripotency factors regulate definitive endoderm specification through eomesodermin

1 reference

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27 July 2018

Myc represses primitive endoderm differentiation in pluripotent stem cells.

1 reference

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27 July 2018

The ground state of pluripotency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling

1 reference

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27 July 2018

The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming

1 reference

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27 July 2018

Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal

1 reference

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27 July 2018

A genetically encoded fluorescent sensor of ERK activity

1 reference

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27 July 2018

Analysis of the factors that limit the ability of feeder cells to maintain the undifferentiated state of human embryonic stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

The ground state of embryonic stem cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Molecular and biological properties of pluripotent embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

New cell lines from mouse epiblast share defining features with human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Patterning the early Xenopus embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Derivation of human embryonic stem cells in defined conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Transcriptional regulation of mesendoderm formation in Xenopus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Efficient differentiation of human embryonic stem cells to definitive endoderm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Mesoderm induction by activin requires FGF-mediated intracellular signals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

27 July 2018

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

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Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Basic fibroblast growth factor support of human embryonic stem cell self-renewal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

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LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294294

25 September 2018

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22385658

12 December 2020

based on heuristic

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10.1016/J.STEM.2012.01.014

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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