(Q35804150)

10 August 2017

In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine (English)

1 reference

10 August 2017

Sam Boase

1

1 reference

10 August 2017

John O Miners

series ordinal

2

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 November 2002

1 reference

British Journal of Clinical Pharmacology

10 August 2017

1 reference

10 August 2017

54

1 reference

10 August 2017

5

1 reference

10 August 2017

493-503

1 reference

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Nonspecific binding of drugs to human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Structural and functional studies of UDP-glucuronosyltransferases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Glucuronidation of diflunisal in liver and kidney microsomes of rat and man.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

The pharmacokinetics of naproxen, its metabolite O-desmethylnaproxen, and their acyl glucuronides in humans. Effect of cimetidine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Intravascular distribution of zidovudine: role of plasma proteins and whole blood components.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Gender and oral contraceptive steroids as determinants of drug glucuronidation: effects on clofibric acid elimination

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Discrepancies between pharmacokinetic studies of amitriptyline.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Characterisation of theophylline metabolism in human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Disposition of propofol administered as constant rate intravenous infusions in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Pharmacokinetics and protein binding of propofol in patients with cirrhosis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Drug glucuronidation in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Extrahepatic metabolism of zidovudine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Commentary: a physiological approach to hepatic drug clearance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

27 July 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Influence of sex and oral contraceptive steroids on paracetamol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha-naphthoflavone, terfenadine and testosterone.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Lamotrigine clinical pharmacokinetics

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874472

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

25 September 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Salivary secretion of paracetamol in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Determination of blood and other tissue concentrations of paracetamol in dog and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2002.01669.X

Conformational change of cytochrome P450 1A2 induced by sodium chloride

21 January 2018

1 reference

12 December 2020

Preclinical prediction of factors influencing the elimination of 5,6-dimethylxanthenone-4-acetic acid, a new anticancer drug

1 reference

12 December 2020

Effect of naproxen co-administration on valproate disposition

1 reference

12 December 2020

UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene

1 reference

12 December 2020

Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration

1 reference

12 December 2020

Species differences in the metabolic conjugation of clofibric acid and clofibrate in laboratory animals and man

1 reference

12 December 2020

Naloxone protein binding in adult and foetal plasma

1 reference

12 December 2020

Comparative study of clofibric acid and bilirubin glucuronidation in human liver microsomes

1 reference

12 December 2020

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine

1 reference

12 December 2020

Kinetic and inhibitor studies of 4-methylumbelliferone and 1-naphthol glucuronidation in human liver microsomes

1 reference

12 December 2020

Pharmacokinetics and bioavailability of zidovudine in humans

1 reference

12 December 2020

Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomes

1 reference

12 December 2020

In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes

1 reference

12 December 2020

10.1046/J.1365-2125.2002.01669.X

Identifiers

DOI

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

12445028

1 reference