(Q35815863)

10 August 2017

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer (English)

1 reference

10 August 2017

6

Ankit Malik

1 reference

10 August 2017

Rajendra Karki

5

0 references

Zhiping Liu

Zhiping Liu

4

0 references

Prajwal Gurung

Prajwal Gurung

10

0 references

Si Ming Man

Si Ming Man

1

0 references

Peter Vogel

Peter Vogel

Thirumala-Devi Kanneganti

17

0 references

Thirumala-Devi Kanneganti

19

0 references

author name string

Qifan Zhu

2

1 reference

10 August 2017

Liqin Zhu

3

1 reference

10 August 2017

Deepika Sharma

7

1 reference

10 August 2017

Liyuan Li

8

1 reference

10 August 2017

R K Subbarao Malireddi

9

1 reference

10 August 2017

Geoffrey Neale

11

1 reference

10 August 2017

Scott R Olsen

12

1 reference

10 August 2017

Robert A Carter

13

1 reference

10 August 2017

Daniel J McGoldrick

14

1 reference

10 August 2017

Gang Wu

15

1 reference

10 August 2017

David Finkelstein

16

1 reference

10 August 2017

Richard J Gilbertson

18

1 reference

10 August 2017

language of work or name

English

0 references

publication date

18 June 2015

1 reference

10 August 2017

1 reference

10 August 2017

162

1 reference

10 August 2017

1

1 reference

10 August 2017

45-58

1 reference

Regulation of inflammasome activation

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The landscape of microsatellite instability in colorectal and endometrial cancer genomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The gut microbiome modulates colon tumorigenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Crypt stem cells as the cells-of-origin of intestinal cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Linking colorectal cancer to Wnt signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Phosphorylation of the PTEN tail regulates protein stability and function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

A comprehensive look at transcription factor gene expression changes in colorectal adenomas

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Lung cancer: New biological insights and recent therapeutic advances

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Wnt proteins are lipid-modified and can act as stem cell growth factors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4491002

Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma

22 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26095253

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26095253

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HNPCC-associated small bowel cancer: clinical and molecular characteristics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26095253

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2015.06.001

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

26095253

1 reference