(Q35826664)

10 August 2017

A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis (English)

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10 August 2017

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Michael G Berg

1

1 reference

10 August 2017

Lili Wan

2

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10 August 2017

Ihab Younis

3

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10 August 2017

Michael D Diem

4

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10 August 2017

Michael Soo

5

1 reference

10 August 2017

Congli Wang

6

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10 August 2017

Gideon Dreyfuss

7

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10 August 2017

language of work or name

English

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publication date

17 January 2012

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Molecular and Cellular Biology

10 August 2017

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10 August 2017

32

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10 August 2017

7

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10 August 2017

1271-1283

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describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3302438/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

27 July 2018

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Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.

27 July 2018

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The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo

27 July 2018

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Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

27 July 2018

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27 July 2018

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The spliceosome: design principles of a dynamic RNP machine

27 July 2018

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Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

27 July 2018

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Alternative splicing and disease

27 July 2018

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A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

27 July 2018

1 reference

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Inactivation of the SMN complex by oxidative stress

27 July 2018

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

27 July 2018

1 reference

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What's new on CDC25 phosphatase inhibitors

27 July 2018

1 reference

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Utilization of host SR protein kinases and RNA-splicing machinery during viral replication

27 July 2018

1 reference

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Alternative splicing: new insights from global analyses

27 July 2018

1 reference

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The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

27 July 2018

1 reference

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Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe.

27 July 2018

1 reference

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The spliceosome: a novel multi-faceted target for therapy

27 July 2018

1 reference

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The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase

27 July 2018

1 reference

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

27 July 2018

1 reference

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Manipulation of alternative splicing by a newly developed inhibitor of Clks

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The Prp19p-associated complex in spliceosome activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Pre-mRNA splicing: awash in a sea of proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

How introns influence and enhance eukaryotic gene expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Messenger-RNA-binding proteins and the messages they carry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

A cyclophilin functions in pre-mRNA splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Mechanical devices of the spliceosome: motors, clocks, springs, and things

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Prp43: An RNA helicase-like factor involved in spliceosome disassembly

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Cantharidin-binding protein: identification as protein phosphatase 2A

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Alternative isoform regulation in human tissue transcriptomes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Isolation of an active step I spliceosome and composition of its RNP core.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Enzymes catalyzing protein folding and their cellular functions

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Alternative splicing: a new drug target of the post-genome era.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

eIF4A3 is a novel component of the exon junction complex

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302438

Inhibition of pre-mRNA splicing by cisplatin and platinum analogs

24 September 2018

1 reference

12 December 2020

PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo

1 reference

12 December 2020

PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins

1 reference

12 December 2020

Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.05788-11

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22252314

1 reference