(Q35828036)

10 August 2017

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title

Human carbonyl reduction pathways and a strategy for their study in vitro (English)

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10 August 2017

M Jane Cox Rosemond

1

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10 August 2017

John S Walsh

series ordinal

2

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

published in

Drug Metabolism Reviews

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10 August 2017

volume

36

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10 August 2017

issue

2

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10 August 2017

page(s)

335-361

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Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers

10 August 2017

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1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Mechanism of human aldehyde reductase: characterization of the active site pocket

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120034154

Stereoselectivity of idarubicin reduction in various animal species and humans

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120034154

Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Structure and mechanism of cytosolic quinone reductases

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120034154

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Human 11beta-hydroxysteroid dehydrogenase 1/carbonyl reductase: additional domains for membrane attachment?

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-120034154

Endogenous inhibitors of 11 beta-OHSD: existence and possible significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Aldo-keto reductases as modulators of stress response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

The use of heterologously expressed drug metabolizing enzymes--state of the art and prospects for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Structural and functional comparison of two human liver dihydrodiol dehydrogenases associated with 3 alpha-hydroxysteroid dehydrogenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Stereospecific reduction of haloperidol in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Mammalian carbonyl reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Structures of mammalian cytosolic quinone reductases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Determination of L-691,121, a new class III antiarrhythmic, and its principal metabolite in plasma by differential radioimmunoassay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

The aldo-keto reductase superfamily homepage

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

The aldo-keto reductase (AKR) superfamily: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Multiplicity of eukaryotic ADH and other MDR forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Pharmacokinetics of haloperidol: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

NRH:quinone oxidoreductase2 (NQO2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

11 beta-Hydroxysteroid dehydrogenase: fact or fancy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Comparative biotransformation and disposition studies of nabumetone in humans and minipigs using high-performance liquid chromatography with ultraviolet, fluorescence and mass spectrometric detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Forms and functions of human SDR enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Short-chain dehydrogenases/reductases (SDR): the 2002 update

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Clinical pharmacokinetics of ketanserin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Kinetics and inhibition of the formation of 6beta-naltrexol from naltrexone in human liver cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Interindividual variation in the enzymatic 15-keto-reduction of 13,14-dihydro-15-keto-prostaglandin E1 in human liver and in human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Biotransformation and detoxification of insecticidal metyrapone analogues by carbonyl reduction in the human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Structural biology of the aldo-keto reductase family of enzymes: catalysis and cofactor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Spiro hydantoin aldose reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Enzyme immunoassays for beta-adrenoreceptor blocking agent, befunolol and its main metabolite, M1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Clinical pharmacokinetics: current requirements and future perspectives from a regulatory point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

11 beta-Hydroxysteroid dehydrogenase: implications for clinical medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Recent studies of aldose reductase enzyme inhibition for diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Characterization of a major form of human isatin reductase and the reduced metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

High-performance liquid-chromatographic-atmospheric-pressure chemical-ionization ion-trap mass-spectrometric identification of isomeric C6-hydroxy and C20-hydroxy metabolites of methylprednisolone in the urine of patients receiving high-dose pulse t

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Species differences in the chirality of the carbonyl reduction of [14C] fenofibrate in laboratory animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Immunohistochemical localization of carbonyl reductase in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Characterization of a novel variant (S145C/L311V) of 3 ??-hydroxysteroid/dihydrodiol dehydrogenase in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

Linkage mapping of the carbonyl reductase (CBR) gene on human chromosome 21 using a DNA polymorphism in the 3′ untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034154

21 January 2018

Identifiers

DOI

10.1081/DMR-120034154

1 reference

10 August 2017

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