(Q35828726)

English

Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information

scientific article published in May 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 August 2017

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Europe PubMed Central

Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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author name string

Edward A Lock

1

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Europe PubMed Central

PubMed publication ID

10 August 2017

Gordon C Hard

2

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Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

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publication date

1 May 2004

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Europe PubMed Central

PubMed publication ID

10 August 2017

Critical Reviews in Toxicology

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Europe PubMed Central

PubMed publication ID

10 August 2017

34

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Europe PubMed Central

PubMed publication ID

10 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

211-299

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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Alpha 2 mu-globulin nephropathy in white ravens

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Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.

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Biotransformation and male rat-specific renal toxicity of diethyl ethyl- and dimethyl methylphosphonate.

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Renal lesions induced by ochratoxin A exposure in the F344 rat

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Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies

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Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice.

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Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: A case study using alkyl phthalates

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Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction.

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Metabolism of the flame retardant plasticizer tris(2-chloroethyl)phosphate by human and rat liver preparations*1

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Involvement of reversible binding to alpha 2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity

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Organotropic formation and disappearance of 8-hydroxydeoxyguanosine in the kidney of Sprague-Dawley rats exposed to adriamycin and KBrO3.

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Cell proliferation in carcinogenesis

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In vitro metabolism of chloroprene: species differences, epoxide stereochemistry and a de-chlorination pathway

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Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

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Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

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Lindane induces nephropathy and renal accumulation of α2u-globulin in male but not in female Fischer 344 rats or male NBR rats

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Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: predictive nature and comparison to lesions induced by genotoxic carcinogens

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Alpha 2u-globulin nephropathy and carcinogenicity following exposure to decalin (decahydronaphthalene) in F344/N rats

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Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat.

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Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example

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Toxicity and carcinogenicity studies of quercetin, a natural component of foods

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Development of kidney tumors in the male F344/N rat after treatment with dimethyl methylphosphonate.

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Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens

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Measurement of nuclear DNA modification by 32P-postlabeling in the kidneys of male and female Fischer 344 rats after multiple gavage doses of hydroquinone.

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The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies

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Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice

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The role of 8-hydroxyguanine in carcinogenesis

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21 January 2018

Inhalation carcinogenicity of trichloroethylene in mice and rats.

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21 January 2018

Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals

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Investigations on cell proliferation and enzyme induction in male rat kidney and female mouse liver caused by tetrahydrofuran

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Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes

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Carcinogenicity of bromodichloromethane administered in drinking water to Male F344/N Rats and B6C3F1 mice

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Mutagenicity of cosmetics ingredients licensed by the European Communities.

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Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.

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Potential role of alpha-2 mu-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane

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Chronic Progressive Nephrosis in the Albino Rat

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Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes

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The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.

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Formic acid excretion in rats exposed to trichloroethylene: a possible explanation for renal toxicity in long-term studies.

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Mutagenicity of benzoquinones for Ames Salmonella tester strains

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High frequency, single-dose model of renal adenoma/carcinoma induction using dimethylnitrosamine in Crl:(W)BR rats.

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Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk

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Risk assessment of d-limonene: an example of male rat-specific renal tumorigens.

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Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy

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Short-term toxicity and reproduction studies in rats with hexachloro-(1,3)-butadiene

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Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay.

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Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species.

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In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene

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Carcinogenicity examination of quercetin and rutin in ACI rats

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1,2,3-Trichloropropane: a multisite carcinogen in rats and mice

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Lack of carcinogenicity of quercetin in F344/DuCrj rats.

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Long-term exposure to the anti-inflammatory agent phenylbutazone induces kidney tumors in rats and liver tumors in mice

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Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice

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Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

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Results of a two year chronic toxicity study with hexachlorobutadiene in rats

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The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane

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Modes of action of trichloroethylene for kidney tumorigenesis

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Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone.

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d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin

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d-Limonene induced hyaline droplet nephropathy in alpha 2u-globulin transgenic mice

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Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates.

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Critique does not validate assumptions in the model on alpha 2u-globulin and renal carcinogenesis.

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Renal-cell carcinoma

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Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA.

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Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate

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Effect of hexachloro-1,3-butadiene on renal carcinogenesis in male rats pretreated with N-ethyl-N-hydroxyethylnitrosamine

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Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes.

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The metabolism and nephrotoxicity of tetrafluoroethylene in the rat.

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The role of glutathione in DNA damage by potassium bromate in vitro

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Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S-yl)hydroquinone

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Test of carcinogenicity of quercetin, a widely distributed mutagen in food

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Induction of Renal Cell Tumors in Rats and Mice, and Enhancement of Hepatocellular Tumor Development in Mice after Long-term Hydroquinone Treatment

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Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases

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Potential health impacts of excessive flavonoid intake

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Evaluation of potential modes of action of inhaled ethylbenzene in rats and mice

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Chloroprene and isoprene: cytogenetic studies in mice.

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DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate.

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Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate

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Cytotoxic and mutagenic effects of ferric nitrilotriacetate on L5178Y mouse lymphoma cells.

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Induction of a wide range of C(2-12) aldehydes and C(7-12) acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate.

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The toxicology of mycotoxins

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21 January 2018

Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates

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21 January 2018

Mutagenicity of tetrachloroethene in the Ames test--metabolic activation by conjugation with glutathione.

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21 January 2018

Metabolism and molecular toxicology of isoprene

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21 January 2018

A mechanistic interpretation of the oncogenicity of chlorothalonil in rodents and an assessment of human relevance

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21 January 2018

P-Nitrobenzoic acid alpha2u nephropathy in 13-week studies is not associated with renal carcinogenesis in 2-year feed studies

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21 January 2018

Characterization of tert-butyl alcohol binding to alpha2u-globulin in F-344 rats

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21 January 2018

Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent

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21 January 2018

A review of the environmental and mammalian toxicology of nitrilotriacetic acid

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21 January 2018

LETTERS TO THE EDITOR

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21 January 2018

Chloroform-induced cytotoxicity and regenerative cell proliferation in the kidneys and liver of BDF1 mice

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21 January 2018

Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

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21 January 2018

Glutathione-dependent bioactivation of haloalkenes

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21 January 2018

Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds

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21 January 2018

Age-associated lesions in barrier-reared male Sprague-Dawley rats: a comparison between Hap: (SD) and Crl:COBS[R]CD[R](SD) stocks

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21 January 2018

Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol

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Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice

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21 January 2018

Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD-1 mice

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21 January 2018

Tumor induction in F344/N rats and B6C3F1 mice following inhalation exposure to ethylbenzene

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21 January 2018

Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water

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21 January 2018

Cell proliferation and carcinogenesis

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21 January 2018

?2u-Globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl)cyclohexaneacetic acid

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https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Perchloroethylene-induced rat kidney tumors: an investigation of the mechanisms involved and their relevance to humans

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Formation of ochratoxin A metabolites and DNA-adducts in monkey kidney cells

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Mutagenicity of dihydroxybenzenes and dihydroxynaphthalenes for Ames Salmonella tester strains.

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Re-evaluation of the 2-year chloroform drinking water carcinogenicity bioassay in Osborne-Mendel rats supports chronic renal tubule injury as the mode of action underlying the renal tumor response

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

The role of proliferation in the origin of mutations in mammalian cells

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Increased levels of DNA synthesis in hyperplastic renal tubules of aging nephropathy in female F344/NCr rats

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

DNA adduct formation in B6C3F1 mice and Fischer-344 rats exposed to 1,2,3-trichloropropane

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Toxicity and cell proliferation in the liver, kidneys and nasal passages of female F-344 rats, induced by chloroform administered by gavage

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Linking the metabolism of hydroquinone to its nephrotoxicity and nephrocarcinogenicity

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Cigarette smoke-induced DNA-damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Effect of renal formic acid excretion on urinary calcium and ammonia concentrations

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Kinetics and renal effects of formic acid in occupationally exposed farmers

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

The acute toxic effects of hexachloro-1 : 3-butadiene on the rat kidney

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Cytosolic C-S lyase activity in human kidney samples-relevance for the nephrotoxicity of halogenated alkenes in man

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

In vitro DNA and dGMP adducts formation caused by ochratoxin A

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Increased hyaline droplet formation in male rats exposed to decalin in dependent on the presence of ?2u-globulin*1

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Biotransformation of the fungicide chlorthalonil by glutathione conjugation

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Toxicological profile for o-benzyl-p-chlorophenol

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

A PATHOLOGICAL STUDY ON THE TOXICITY OF S-DICHLOROVINYL-L-CYSTEINE

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Mechanism of benzene toxicity. Effects of benzene and benzene metabolites on bone marrow cellularity, number of granulopoietic stem cells and frequency of micronuclei in mice

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Cell proliferation induced in the kidneys and livers of rats and mice by short term exposure to the carcinogen p-dichlorobenzene

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Mechanisms of DNA damage induced in rat hepatocytes by quinones

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

A 90-day study in rats with the monoglutathione conjugate of chlorothalonil

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules

1 reference

https://api.crossref.org/works/10.1080%2F10408440490265210

21 January 2018

Identifiers

10.1080/10408440490265210

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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