(Q35830390)

10 August 2017

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title

In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire (English)

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10 August 2017

Ferenc Livák

1

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10 August 2017

publication date

1 August 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

200

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10 August 2017

page(s)

23-35

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Somatic generation of antibody diversity

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

21 January 2018

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

21 January 2018

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In vitro V(D)J recombination: signal joint formation

21 January 2018

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RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

21 January 2018

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RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

21 January 2018

1 reference

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V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

21 January 2018

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Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences

21 January 2018

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Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

21 January 2018

1 reference

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

21 January 2018

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Assembly of the RAG1/RAG2 synaptic complex

21 January 2018

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.

21 January 2018

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Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

21 January 2018

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DNA hairpin opening mediated by the RAG1 and RAG2 proteins

21 January 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

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The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

1 reference

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Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

21 January 2018

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Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Rejoining of DNA by the RAG1 and RAG2 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Postcleavage sequence specificity in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Structural basis of T cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

How many thymocytes audition for selection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Evolutionarily conserved pattern of gene segment usage within the mammalian TCRbeta locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Genetic modulation of T cell receptor gene segment usage during somatic recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The role of components of recombination signal sequences in immunoglobulin gene segment usage: a V81x model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer Sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

T-cell receptor delta gene rearrangements in early thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Recombination signal sequence variations and the mechanism of patterned T-cell receptor-beta locus rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

DNA-Rag Protein Interactions in the Control of Selective D Gene Utilization in the TCRβ Locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Evolution of the recombination signal sequences in the Ig heavy-chain variable region locus of mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Why PLoS became a publisher

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The B12/23 restriction is critically dependent on recombination signal nonamer and spacer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Ordered assembly of the V(D)J synaptic complex ensures accurate recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The kinetics of V-J joining throughout 3.5 megabases of the mouse Ig kappa locus fit a constrained diffusion model of nuclear organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Chromosomal translocations in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Cryptic signals and the fidelity of V(D)J joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Interfaces between the detection, signaling, and repair of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Identification of V(D)J recombination coding end intermediates in normal thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Chromosomal breakage syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Sensing of intermediates in V(D)J recombination by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

RAG transposase can capture and commit to target DNA before or after donor cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

High mobility of proteins in the mammalian cell nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Spatial and temporal cellular responses to single-strand breaks in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

New insights into V(D)J recombination and its role in the evolution of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vβ analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00170.X

10.1111/J.0105-2896.2004.00170.X

21 January 2018

Identifiers

DOI

1 reference

release_xg7y3bconnckjg2kzntgrwssgi

10 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xg7y3bconnckjg2kzntgrwssgi

mapped directly with Wikidata item

24 November 2022

based on heuristic

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