(Q35838961)

English

Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.

scientific article published on 4 January 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219182%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219182%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

2

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19 January 2020

author name string

Mei-Ren Pan

1

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19 January 2020

Hui Dai

3

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19 January 2020

Wen-Chun Hung

4

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19 January 2020

Kaiyi Li

5

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19 January 2020

Guang Peng

6

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19 January 2020

Shiaw-Yih Lin

7

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19 January 2020

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4 January 2012

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19 January 2020

Journal of Biological Chemistry

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19 January 2020

287

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19 January 2020

9

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19 January 2020

6764-6772

1 reference

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19 January 2020

Cancer biology and NuRD: a multifaceted chromatin remodelling complex

1 reference

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27 July 2018

SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation

1 reference

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27 July 2018

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

ATM mediated phosphorylation of CHD4 contributes to genome maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

1 reference

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27 July 2018

BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

1 reference

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27 July 2018

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

1 reference

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27 July 2018

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

1 reference

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27 July 2018

Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Chromatin dynamics and the preservation of genetic information

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

H2AX: the histone guardian of the genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

The BRCT Domain Is a Phospho-Protein Binding Domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Molecular views of recombination proteins and their control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3307306

27 July 2018

Homologous repair of DNA damage and tumorigenesis: the BRCA connection

1 reference

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27 July 2018

Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks

1 reference

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27 July 2018

Double-strand breaks and tumorigenesis

1 reference

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27 July 2018

Mi2, an auto-antigen for dermatomyositis, is an ATP-dependent nucleosome remodeling factor

1 reference

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27 July 2018

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1 reference

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27 July 2018

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

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27 July 2018

Role of poly(ADP-ribose) formation in DNA repair

1 reference

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27 July 2018

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

1 reference

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Regulation of homologous recombination in eukaryotes

1 reference

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24 September 2018

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

1 reference

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24 September 2018

Poly ADP-ribose polymerase-1: an international molecule of mystery

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer

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12 December 2020

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inferred from PubMed ID database lookup

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10.1074/JBC.M111.287037

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219182%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219182%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22219182%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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