(Q35840689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Morag A Lewis

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Mhamed Grati

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

8

Karen P Steel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Jennifer M Hilton

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Neil Ingham

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Selina Pearson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

David J Adams

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

publication date

21 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

page(s)

R90

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1186/gb-2011-12-9-r90

13 February 2020

exact match

0 references

cites work

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Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear

11 July 2018

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IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

11 July 2018

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Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa

11 July 2018

1 reference

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Unraveling the genetics of otitis media: from mouse to human and back again

11 July 2018

1 reference

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Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse

11 July 2018

1 reference

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Massively parallel sequencing and rare disease

11 July 2018

1 reference

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Exome sequencing makes medical genomics a reality

11 July 2018

1 reference

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The Pfam protein families database

11 July 2018

1 reference

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Otitis media in a mouse model for Down syndrome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Mucin gene polymorphisms in otitis media patients.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The Sequence Alignment/Map format and SAMtools

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Fast and accurate short read alignment with Burrows-Wheeler transform

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Inactivation of Chibby affects function of motile airway cilia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice

11 July 2018

1 reference

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11 July 2018

1 reference

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Myeloid differentiation primary response gene 88 is required for the resolution of otitis media

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

A mouse model with postnatal endolymphatic hydrops and hearing loss

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Eya4-deficient mice are a model for heritable otitis media

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Chronic and recurrent otitis media: a genome scan for susceptibility loci

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

SWISS-MODEL: An automated protein homology-modeling server

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Decoding the LIM development code.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Series introduction. JAK-STAT signaling in human disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Cell biology of tubotympanum in relation to pathogenesis of otitis media - a review

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

dbSNP: the NCBI database of genetic variation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

E2F4 is essential for normal erythrocyte maturation and neonatal viability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Primer3 on the WWW for general users and for biologist programmers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Galanin and somatostatin inhibition of substance P-induced airway mucus secretion in the rat.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

HLA Frequency in Patients With Recurrent Acute Otitis Media

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Normal hearing in Splotch (Sp/+), the mouse homologue of Waardenburg syndrome type 1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Complications of chronic suppurative otitis media and their management.

11 July 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

FBXO11, a regulator of the TGFβ pathway, is associated with severe otitis media in Western Australian children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

C3H/HeJ mouse model for spontaneous chronic otitis media.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

The role of Fas-mediated apoptosis in otitis media: observations in the lpr/lpr mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

A novel model of murine mucopolysaccharidosis type VII due to an intracisternal a particle element transposition into the beta-glucuronidase gene: clinical and pathologic findings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Evaluation of the polymorphism in the Toll-like receptor 4 (TLR4) genes of tympanosclerosis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Removal of an intra-parotid foreign body without parotidectomy and dissection of the facial nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

The LIM-homeodomain protein Isl-1 segregates with somatostatin but not with gastrin expression during differentiation of somatostatin/gastrin precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FGB-2011-12-9-R90

Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308053

Recurrent otitis media: genetic immunoglobulin markers in children and their parents

24 September 2018

1 reference

12 December 2020

Role of Toll-like receptor 4 in innate immune responses in a mouse model of acute otitis media

1 reference

12 December 2020

Spontaneous development of otitis media in plasminogen-deficient mice

1 reference

12 December 2020

Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media

1 reference

12 December 2020

Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children

1 reference

12 December 2020

Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media

1 reference

12 December 2020

The heritability of otitis media: a twin and triplet study

1 reference

12 December 2020

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

1 reference

12 December 2020

Identifiers

DOI

10.1186/GB-2011-12-9-R90

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21936904%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference