(Q35842099)

English

Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling

scientific article published on 6 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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Andreas Plückthun

object named as

Andreas Plückthun

5

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author name string

Ykelien L Boersma

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Ginger Chao

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Daniel Steiner

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

K Dane Wittrup

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

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publication date

6 October 2011

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Europe PubMed Central

PMC publication ID

10 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

286

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

48

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

41273-41285

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Non-immunoglobulin based protein scaffolds.

1 reference

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DARPins and other repeat protein scaffolds: advances in engineering and applications

1 reference

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A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth.

1 reference

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A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity

1 reference

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11 July 2018

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling.

1 reference

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Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size

1 reference

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Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy.

1 reference

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EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins

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Different antiproliferative effects of matuzumab and cetuximab in A431 cells are associated with persistent activity of the MAPK pathway

1 reference

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Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor

1 reference

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Anti-epidermal growth factor receptor monoclonal antibody cetuximab inhibits EGFR/HER-2 heterodimerization and activation

1 reference

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Interaction of antibodies with ErbB receptor extracellular regions

1 reference

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EGFR family: structure physiology signalling and therapeutic targets

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Efficient selection of DARPins with sub-nanomolar affinities using SRP phage display

1 reference

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ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium

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Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425

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11 July 2018

Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization

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Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8

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Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands

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ErbB-directed immunotherapy: antibodies in current practice and promising new agents

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Biological activity in vitro of anti-epidermal growth factor receptor monoclonal antibodies with different affinities.

1 reference

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The HER family and cancer: emerging molecular mechanisms and therapeutic targets

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Cetuximab: appraisal of a novel drug against colorectal cancer.

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A designed ankyrin repeat protein evolved to picomolar affinity to Her2

1 reference

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Clonogenic assay of cells in vitro.

1 reference

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Analysis of apoptosis by propidium iodide staining and flow cytometry

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11 July 2018

Unligated epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308840

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Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target

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EGFR targeting therapies: monoclonal antibodies versus tyrosine kinase inhibitors. Similarities and differences.

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Isolation of intracellular proteinase inhibitors derived from designed ankyrin repeat proteins by genetic screening

1 reference

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The epidermal growth factor receptor pathway: a model for targeted therapy

1 reference

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Selection and characterization of Her2 binding-designed ankyrin repeat proteins

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Effect of the anti-receptor ligand-blocking 225 monoclonal antibody on EGF receptor endocytosis and sorting

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments

1 reference

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High-affinity binders selected from designed ankyrin repeat protein libraries

1 reference

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ErbB receptors: directing key signaling networks throughout life

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Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

1 reference

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Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

1 reference

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Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies

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Transmembrane signaling by epidermal growth factor receptors lacking autophosphorylation sites.

1 reference

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Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies.

1 reference

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Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

1 reference

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Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1 reference

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Structural basis for inhibition of the epidermal growth factor receptor by cetuximab

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Chemoprevention of breast cancer: a model for change

1 reference

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24 September 2018

Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase acti

1 reference

https://pubmed.ncbi.nlm.nih.gov/21979953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.293266

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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