(Q35849255)

English

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

scientific article published on 17 January 2012

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. (English)

1 reference

Europe PubMed Central

10 August 2017

27

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Guido Marcucci

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Konstanze Döhner

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Konstanze Dohner

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Clara D. Bloomfield

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Clara D Bloomfield

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Kati Maharry

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Bob Lowenberg

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Michael A Caligiuri

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Michael A Caligiuri

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Janet D Rowley

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Michelle M Le Beau

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Michelle M Le Beau

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Richard A. Larson

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Richard A Larson

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Yves A. Lussier

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Yves A Lussier

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Stephen Arnovitz

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Stephen Arnovitz

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Mary Beth Neilly

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Mary Beth Neilly

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Paul P Liu

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Peter J M Valk

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Xinan Yang

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Lars Bullinger

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Colles Price

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10 August 2017

author name string

Zejuan Li

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10 August 2017

Hao Huang

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10 August 2017

Yuanyuan Li

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Xi Jiang

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10 August 2017

Ping Chen

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Michael D Radmacher

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Abdel Elkahloun

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Chunjiang He

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Miao He

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Zhiyu Zhang

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Yanming Zhang

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Ruud Delwel

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Jianjun Chen

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10 August 2017

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publication date

17 January 2012

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10 August 2017

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10 August 2017

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

The prognostic and functional role of microRNAs in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

The Hox genes and their roles in oncogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Targeting HOX and PBX transcription factors in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Leukemogenic transformation by HOXA cluster genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Leukaemogenesis: more than mutant genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

The molecular biology of mixed lineage leukemia

1 reference

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11 July 2018

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

HOXA9 is required for survival in human MLL-rearranged acute leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

HOX proteins and leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

HOX expression patterns identify a common signature for favorable AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MicroRNA expression in cytogenetically normal acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

miR-181a is an intrinsic modulator of T cell sensitivity and selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Oncomirs - microRNAs with a role in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

A microRNA polycistron as a potential human oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MLL: how complex does it get?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MicroRNAs: small RNAs with a big role in gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MicroRNAs modulate hematopoietic lineage differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

11 July 2018

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

1 reference

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11 July 2018

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

1 reference

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11 July 2018

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3311258

24 September 2018

Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities.

1 reference

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24 September 2018

Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22251480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22251480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

1 reference

https://pubmed.ncbi.nlm.nih.gov/22251480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A paradigm for class prediction using gene expression profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/22251480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2011-10-386235

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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