(Q35874442)

English

Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation

scientific article published on 16 February 2012

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23 January 2020

Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation (English)

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Europe PubMed Central

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23 January 2020

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cannabinoid receptor

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Mariam M Mahmoud

2

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23 January 2020

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Kwang H Ahn

1

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23 January 2020

Debra A Kendall

3

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23 January 2020

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16 February 2012

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23 January 2020

Journal of Biological Chemistry

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23 January 2020

287

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23 January 2020

15

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23 January 2020

12070-12082

1 reference

Europe PubMed Central

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23 January 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3320953/fullTextXML

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Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

1 reference

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Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide

1 reference

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β-Arrestin-mediated receptor trafficking and signal transduction

1 reference

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11 July 2018

The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network.

1 reference

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11 July 2018

Crystal structure of metarhodopsin II

1 reference

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11 July 2018

The structural basis of agonist-induced activation in constitutively active rhodopsin

1 reference

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Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.

1 reference

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

1 reference

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11 July 2018

Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation

1 reference

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11 July 2018

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics

1 reference

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11 July 2018

Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias

1 reference

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11 July 2018

Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Multiple switches in G protein-coupled receptor activation

1 reference

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11 July 2018

Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization

1 reference

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11 July 2018

Signal transduction of the CB1 cannabinoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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11 July 2018

Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells

1 reference

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11 July 2018

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Beta-arrestin-biased ligands at seven-transmembrane receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Conformational complexity of G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

The emerging functions of endocannabinoid signaling during CNS development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

A guided tour into subcellular colocalization analysis in light microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Cannabinoid receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Allosteric modulation of the cannabinoid CB1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Constitutive endocytic cycle of the CB1 cannabinoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

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11 July 2018

Retrograde signaling by endocannabinoids

1 reference

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11 July 2018

G protein-coupled receptor allosterism and complexing

1 reference

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11 July 2018

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

1 reference

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11 July 2018

The endocannabinoid nervous system: unique opportunities for therapeutic intervention

1 reference

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11 July 2018

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

1 reference

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11 July 2018

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Cellular signal transduction by anandamide and 2-arachidonoylglycerol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Effects of cannabinoids on energy metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes.

1 reference

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11 July 2018

Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

11 July 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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11 July 2018

High-efficiency transformation of mammalian cells by plasmid DNA

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11 July 2018

Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

24 September 2018

Allosteric modulation of muscarinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

24 September 2018

How does arrestin assemble MAPKs into a signaling complex?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

24 September 2018

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

24 September 2018

Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320953

24 September 2018

Allosteric modulators affect the internalization of human adenosine A1 receptors

1 reference

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24 September 2018

Integrity of extracellular loop 1 of the human cannabinoid receptor 1 is critical for high-affinity binding of the ligand CP 55,940 but not SR 141716A

1 reference

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24 September 2018

Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

1 reference

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24 September 2018

Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus

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24 September 2018

The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan.

1 reference

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24 September 2018

Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization

1 reference

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24 September 2018

Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.

1 reference

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24 September 2018

Cannabinoid transmission and reward-related events

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24 September 2018

Functional Microdomains in G-protein-coupled Receptors

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21 January 2018

The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22343625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22343625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid receptor CB1 activates the Na+/H+ exchanger NHE-1 isoform via Gi-mediated mitogen activated protein kinase signaling transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22343625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalization and Recycling of the CB1 Cannabinoid Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22343625

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.316463

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22343625%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22343625%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22343625%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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