(Q35878807)

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A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

scientific article published on 7 February 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets (English)

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Europe PubMed Central

PMC publication ID

10 August 2017

Heike Irmgard Grabsch

27

object named as

Heike Grabsch

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PMC publication ID

10 August 2017

object named as

Hannah Wang

3

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object named as

Niantao Deng

1

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object named as

Kakoli Das

4

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Alex Boussioutas

object named as

Alex Boussioutas

26

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author name string

Liang Kee Goh

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Jiong Tao

5

1 reference

Europe PubMed Central

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10 August 2017

Iain Beehuat Tan

6

1 reference

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10 August 2017

Shenli Zhang

7

1 reference

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10 August 2017

Minghui Lee

8

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10 August 2017

Jeanie Wu

9

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10 August 2017

Kiat Hon Lim

10

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10 August 2017

Zhengdeng Lei

11

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10 August 2017

Glenn Goh

12

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10 August 2017

Qing-Yan Lim

13

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10 August 2017

Angie Lay-Keng Tan

14

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10 August 2017

Dianne Yu Sin Poh

15

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10 August 2017

Sudep Riahi

16

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10 August 2017

Sandra Bell

17

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10 August 2017

Michael M Shi

18

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10 August 2017

Ronald Linnartz

19

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10 August 2017

Feng Zhu

20

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10 August 2017

Khay Guan Yeoh

21

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10 August 2017

Han Chong Toh

22

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10 August 2017

Wei Peng Yong

23

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Europe PubMed Central

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10 August 2017

Hyun Cheol Cheong

24

1 reference

Europe PubMed Central

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10 August 2017

Sun Young Rha

25

1 reference

Europe PubMed Central

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10 August 2017

Steve Rozen

28

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Europe PubMed Central

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10 August 2017

Patrick Tan

29

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Europe PubMed Central

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10 August 2017

language of work or name

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publication date

7 February 2012

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Europe PubMed Central

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10 August 2017

full work available at URL

http://eprints.whiterose.ac.uk/105730/

content deliverer

White Rose Research Online

copyright license

Creative Commons Attribution-NonCommercial

0 references

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

61

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Europe PubMed Central

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10 August 2017

5

1 reference

Europe PubMed Central

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10 August 2017

673-684

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

The BATTLE trial: personalizing therapy for lung cancer

1 reference

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11 July 2018

Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Correlation between genomic alterations assessed by array comparative genomic hybridization, prognostically informative histologic subtype, stage, and patient survival in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis

1 reference

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11 July 2018

A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells

1 reference

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11 July 2018

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

1 reference

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11 July 2018

New targeted therapies for gastric cancer

1 reference

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11 July 2018

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients

1 reference

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11 July 2018

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

1 reference

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11 July 2018

Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

1 reference

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11 July 2018

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

1 reference

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11 July 2018

Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis

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11 July 2018

Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

The landscape of somatic copy-number alteration across human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Fibroblast growth factor signalling: from development to cancer

1 reference

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11 July 2018

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Oncogenic pathway combinations predict clinical prognosis in gastric cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Clinical impact of aneuploidy on gastric cancer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Cell cycle kinases as therapeutic targets for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Circos: an information aesthetic for comparative genomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Epidemiology of Stomach Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Somatic mutations affect key pathways in lung adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Assessment of a HER2 scoring system for gastric cancer: results from a validation study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Characterizing the cancer genome in lung adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Lineage dependency and lineage-survival oncogenes in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

11 July 2018

Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma

1 reference

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1 reference

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

1 reference

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11 July 2018

Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3322587

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Loss of WWOX expression in gastric carcinoma

1 reference

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11 July 2018

Alterations of chromosomal copy number during progression of diffuse‐type gastric carcinomas: metaphase‐ and array‐based comparative genomic hybridization analyses of multiple samples from individual tumours

1 reference

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Expression, deletion [was deleton] and mutation of p16 gene in human gastric cancer

1 reference

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Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5.

1 reference

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11 July 2018

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1 reference

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1 reference

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1 reference

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24 September 2018

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24 September 2018

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24 September 2018

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24 September 2018

Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma.

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24 September 2018

Allelic imbalance in gastric cancer: an affected site on chromosome arm 3p.

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24 September 2018

Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma

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RAF/RAS oncogenes and mismatch-repair status

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14 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BATTLE to personalize lung cancer treatment. Novel clinical trial design and tissue gathering procedures drive biomarker discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I Trial of a Selective c-MET Inhibitor ARQ 197 Incorporating Proof of Mechanism Pharmacodynamic Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification of epidermal growth factor receptor gene and its relationship to survival in human gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22315472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/GUTJNL-2011-301839

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

10.1136/GUTJNL-2011-301839

0 references

0 references

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

0 references

Web of Science work ID

000302776700006

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