(Q37820063)

23 August 2017

2 references

19 July 2021

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets (English)

1 reference

ubiquitin-proteasome system

23 August 2017

0 references

proteasome endopeptidase complex

1 reference

19 July 2021

Lynn Bedford

1

1 reference

23 August 2017

James Lowe

2

1 reference

23 August 2017

Lawrence R Dick

3

1 reference

23 August 2017

R John Mayer

4

1 reference

23 August 2017

James E Brownell

5

1 reference

23 August 2017

language of work or name

1 reference

10 December 2010

1 reference

Nature Reviews Drug Discovery

23 August 2017

1 January 2011

1 reference

19 July 2021

2 references

23 August 2017

19 July 2021

10

1 reference

23 August 2017

29-46

1 reference

23 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd3321

23 August 2017

0 references

cites work

The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

1 reference

Targeting the ubiquitin system in cancer therapy

31 March 2020

1 reference

The ubiquitin proteasome system in neuropathology

31 March 2020

1 reference

Role of the ubiquitin proteasome system in renal cell carcinoma

31 March 2020

1 reference

The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended

31 March 2020

1 reference

The ubiquitin system, disease, and drug discovery

31 March 2020

1 reference

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

31 March 2020

1 reference

E1-L2 activates both ubiquitin and FAT10

31 March 2020

1 reference

Distinct monoubiquitin signals in receptor endocytosis

31 March 2020

1 reference

Ubiquitylation and cell signaling

31 March 2020

1 reference

Proteasome-independent functions of ubiquitin in endocytosis and signaling

31 March 2020

1 reference

Breaking the chains: structure and function of the deubiquitinases

31 March 2020

1 reference

Deubiquitylating enzymes and disease

31 March 2020

1 reference

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

31 March 2020

1 reference

Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer

31 March 2020

1 reference

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

31 March 2020

1 reference

Building ubiquitin chains: E2 enzymes at work

31 March 2020

1 reference

Lingering mysteries of ubiquitin-chain assembly

31 March 2020

1 reference

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

31 March 2020

1 reference

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

31 March 2020

1 reference

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

31 March 2020

1 reference

Function and regulation of cullin-RING ubiquitin ligases

31 March 2020

1 reference

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

31 March 2020

1 reference

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

31 March 2020

1 reference

Identification of a primary target of thalidomide teratogenicity

31 March 2020

1 reference

Defining the human deubiquitinating enzyme interaction landscape

31 March 2020

1 reference

A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling.

31 March 2020

1 reference

Nonproteolytic functions of ubiquitin in cell signaling

31 March 2020

1 reference

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

1 reference

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

31 March 2020

1 reference

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

31 March 2020

1 reference

Direct activation of protein kinases by unanchored polyubiquitin chains

31 March 2020

1 reference

IAPs, RINGs and ubiquitylation

31 March 2020

1 reference

The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination

31 March 2020

1 reference

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

31 March 2020

1 reference

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

31 March 2020

1 reference

A20: from ubiquitin editing to tumour suppression

31 March 2020

1 reference

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

31 March 2020

1 reference

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

31 March 2020

1 reference

Identification of RIP1 kinase as a specific cellular target of necrostatins

31 March 2020

1 reference

RIP kinases at the crossroads of cell death and survival

31 March 2020

1 reference

NF-kappaB modulators in osteolytic bone diseases

31 March 2020

1 reference

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

31 March 2020

1 reference

Functional alterations of cardiac proteasomes under physiological and pathological conditions

31 March 2020

1 reference

Proteasome inhibition during myocardial infarction

31 March 2020

1 reference

Regulatory roles of the ubiquitin-proteasome system in cardiomyocyte apoptosis.

31 March 2020

1 reference

Unexpected cardiotoxicity in haematological bortezomib treated patients

31 March 2020

1 reference

Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy

31 March 2020

1 reference

The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions

31 March 2020

1 reference

Roles of ubiquitination at the synapse

31 March 2020

1 reference

The role of parkin in familial and sporadic Parkinson's disease

31 March 2020

1 reference

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

31 March 2020

1 reference

Is malfunction of the ubiquitin proteasome system the primary cause of alpha-synucleinopathies and other chronic human neurodegenerative disease?

31 March 2020

1 reference

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

31 March 2020

1 reference

Loss of autophagy in the central nervous system causes neurodegeneration in mice

31 March 2020

1 reference

The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen of the other--or not?

31 March 2020

1 reference

Does impairment of the ubiquitin-proteasome system or the autophagy-lysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease?

31 March 2020

1 reference

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

31 March 2020

1 reference

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

31 March 2020

1 reference

Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

31 March 2020

1 reference

A decade of modeling Alzheimer's disease in transgenic mice.

31 March 2020

1 reference

Parkinson's disease: a rethink of rodent models.

31 March 2020

1 reference

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

31 March 2020

1 reference

Potential therapeutic applications of autophagy

31 March 2020

1 reference

Mutations of optineurin in amyotrophic lateral sclerosis

31 March 2020

1 reference

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

31 March 2020

1 reference

Proteasome inhibitors in cancer therapy: lessons from the first decade

31 March 2020

1 reference

Targeted therapy for brain tumours

31 March 2020

1 reference

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

31 March 2020

1 reference

Structure of a Shigella effector reveals a new class of ubiquitin ligases

31 March 2020

1 reference

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

31 March 2020

1 reference

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery

31 March 2020

1 reference

31 March 2020

1 reference

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

31 March 2020

1 reference

Antiviral activity of innate immune protein ISG15.

31 March 2020

1 reference

The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.

31 March 2020

1 reference

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

31 March 2020

1 reference

Listeria monocytogenes ActA-mediated escape from autophagic recognition

31 March 2020

1 reference

Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates

31 March 2020

1 reference

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

31 March 2020

1 reference

Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis

31 March 2020

1 reference

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

31 March 2020

1 reference

"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates

31 March 2020

1 reference

Structural Insights on the Mycobacterium tuberculosis Proteasomal ATPase Mpa

31 March 2020

1 reference

Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity

31 March 2020

1 reference

Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate

31 March 2020

1 reference

Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates

31 March 2020

1 reference

Inhibitors selective for mycobacterial versus human proteasomes

31 March 2020

1 reference

Proteasome inhibitor-based primary therapy for antibody-mediated renal allograft rejection

31 March 2020

1 reference

20S proteasome and its inhibitors: crystallographic knowledge for drug development

31 March 2020

1 reference

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

31 March 2020

1 reference

Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047).

31 March 2020

1 reference

Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia

31 March 2020

1 reference

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

31 March 2020

1 reference

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer

31 March 2020

1 reference

CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib

31 March 2020

1 reference

Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy

31 March 2020

1 reference

Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer

31 March 2020

1 reference

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

31 March 2020

1 reference

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

31 March 2020

1 reference

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

31 March 2020

1 reference

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

31 March 2020

1 reference

Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53

31 March 2020

1 reference

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

31 March 2020

1 reference

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

31 March 2020

1 reference

Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system

31 March 2020

1 reference

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

31 March 2020

1 reference

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

31 March 2020

1 reference

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

31 March 2020

1 reference

Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.

31 March 2020

1 reference

Targeting the SUMO E2 conjugating enzyme Ubc9 interaction for anti-cancer drug design

31 March 2020

1 reference

Targeting Ubc9 for cancer therapy

31 March 2020

1 reference

Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner

31 March 2020

1 reference

Elevated expression of UBE2T in lung cancer tumors and cell lines

31 March 2020

1 reference

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

31 March 2020

1 reference

Association of clinicopathological features with UbcH10 expression in colorectal cancer

31 March 2020

1 reference

E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity

31 March 2020

1 reference

Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78

31 March 2020

1 reference

A conserved catalytic residue in the ubiquitin-conjugating enzyme family.

31 March 2020

1 reference

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

31 March 2020

1 reference

Mechanisms, biology and inhibitors of deubiquitinating enzymes

31 March 2020

1 reference

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

31 March 2020

1 reference

The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways

31 March 2020

1 reference

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

31 March 2020

1 reference

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

31 March 2020

1 reference

Targeting ubiquitin specific proteases for drug discovery

31 March 2020

1 reference

Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease

31 March 2020

1 reference

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

31 March 2020

1 reference

AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4

31 March 2020

1 reference

A novel type of E3 ligase for the Ufm1 conjugation system

31 March 2020

1 reference

Signaling to NF-kappaB: regulation by ubiquitination

31 March 2020

1 reference

"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-kappaB activation

31 March 2020

1 reference

Ubiquitin and ubiquitin-like proteins in protein regulation

31 March 2020

1 reference

Origin and function of ubiquitin-like proteins

31 March 2020

1 reference

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

1 reference

Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.

31 March 2020

1 reference

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes

31 March 2020

1 reference

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

31 March 2020

1 reference

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

31 March 2020

1 reference

31 March 2020

IAPs: what's in a name?

1 reference

XIAP as a ubiquitin ligase in cellular signaling

31 March 2020

1 reference

X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression

31 March 2020

1 reference

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

31 March 2020

1 reference

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

31 March 2020

1 reference

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

31 March 2020

1 reference

The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase

31 March 2020

1 reference

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.

31 March 2020

1 reference

VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment

31 March 2020

1 reference

HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases

31 March 2020

1 reference

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.

31 March 2020

1 reference

Oxygen-independent degradation of HIF-alpha via bioengineered VHL tumour suppressor complex.

31 March 2020

1 reference

Cell death: protein misfolding and neurodegenerative diseases

31 March 2020

1 reference

The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target

31 March 2020

1 reference

The proteasome: a suitable antineoplastic target

31 March 2020

1 reference

The development of proteasome inhibitors as anticancer drugs

31 March 2020

1 reference

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

31 March 2020

1 reference

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

31 March 2020

1 reference

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

31 March 2020

1 reference

A ubiquitin conjugating enzyme encoded by African swine fever virus

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21151032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Parkin and defective ubiquitination in Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21151032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeting E3 ubiquitin ligases for cancer therapy.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21151032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3321

1 reference

23 August 2017

0 references

1 reference