(Q36611534)

English

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

scientific article published on July 2006

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. (English)

1 reference

Europe PubMed Central

15 August 2017

0 references

pharmacodynamics

1 reference

based on heuristic

inferred from title

object named as

C Dive

8

0 references

Gordon C. Jayson

object named as

G Jayson

6

0 references

author name string

J Cummings

1

1 reference

Europe PubMed Central

15 August 2017

M Ranson

2

1 reference

Europe PubMed Central

15 August 2017

E Lacasse

3

1 reference

Europe PubMed Central

15 August 2017

J R Ganganagari

4

1 reference

Europe PubMed Central

15 August 2017

M St-Jean

5

1 reference

Europe PubMed Central

15 August 2017

J Durkin

7

1 reference

Europe PubMed Central

15 August 2017

language of work or name

0 references

publication date

1 July 2006

1 reference

Europe PubMed Central

15 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

15 August 2017

95

1 reference

Europe PubMed Central

15 August 2017

1

1 reference

Europe PubMed Central

15 August 2017

42-48

1 reference

Europe PubMed Central

15 August 2017

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603220

0 references

Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Targeting XIAP for the treatment of malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Biomarkers in cancer staging, prognosis and treatment selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Translational crossroads for biomarkers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Cell death independent of caspases: a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Intrinsic tumour suppression

1 reference

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30 September 2017

Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer

1 reference

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30 September 2017

Apoptotic markers in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Clinical utility of cytokeratins as tumor markers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Keratin 8/18 breakdown and reorganization during apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Circulating tumour markers in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

The quest for the function of simple epithelial keratins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

A novel assay for discovery and characterization of pro-apoptotic drugs and for monitoring apoptosis in patient sera

1 reference

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30 September 2017

Biomarkers in Drug Discovery and Development: From Target Identification through Drug Marketing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Apoptosis-targeted therapies for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Proliferation, cell cycle and apoptosis in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Molecular characterization of a tissue-polypeptide-specific-antigen epitope and its relationship to human cytokeratin 18.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Intermediate filaments: structure, dynamics, function, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Cytokeratins and tissue polypeptide antigen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

30 September 2017

Tissue polypeptide antigen (TPA) is related to the non-epidermal keratins 8, 18 and 19 typical of simple and non-squamous epithelia: re-evaluation of a human tumor marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

28 June 2018

M30 expression demonstrates apoptotic cells, correlates with in situ end-labeling, and is associated with Ki-67 expression in large intestinal neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

28 June 2018

Type I keratin 16 forms relatively unstable tetrameric assembly subunits with various type II keratin partners: biochemical basis and functional implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

28 June 2018

A significant soluble keratin fraction in 'simple' epithelial cells. Lack of an apparent phosphorylation and glycosylation role in keratin solubility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

28 June 2018

Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

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Gene expression profile of inflammatory neutrophils: alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Comprehensive validation of a real-time quantitative bcr-abl assay for clinical laboratory use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Measurement of an apoptotic product in the sera of breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Analytical validation of a real-time reverse transcription-polymerase chain reaction quantitation of different transcripts of the Wilms' tumor suppressor gene (WT1).

1 reference

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20 September 2018

Up-regulation of XIAP by M-CSF is associated with resistance of myeloid leukemia cells to apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differenciation and up-regulation of X-linked inhibitor of apoptosis protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Apoptosis generates stable fragments of human type I keratins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

Heterotypic interactions and filament assembly of type I and type II cytokeratins in vitro: viscometry and determinations of relative affinities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360484

20 September 2018

The role of caspase 3 in producing cytokeratin 19 fragment (CYFRA21-1) in human lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804528

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https://pubmed.ncbi.nlm.nih.gov/16804528

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https://pubmed.ncbi.nlm.nih.gov/16804528

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Rules of evidence for cancer molecular-marker discovery and validation

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https://pubmed.ncbi.nlm.nih.gov/16804528

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Biomarkers: diagnostic highlights and surrogate end points. Cambridge Healthtech Institute's biomarker series: biomarker validation: bringing discovery to the clinic & cancer biomarkers: from discovery to clinical practice. May 3-5, 2004, Philadelph

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https://pubmed.ncbi.nlm.nih.gov/16804528

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Therapy control in oncology by circulating nucleosomes

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https://pubmed.ncbi.nlm.nih.gov/16804528

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Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope m30 in critically ill patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804528

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Biomarker boom slowed by validation concerns

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https://pubmed.ncbi.nlm.nih.gov/16804528

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A novel IRMA and ELISA for quantifying cytokeratin 8 and 18 fragments in the sera of healthy individuals and cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16804528

12 December 2020

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Elevation of anti-cytokeratin 18 antibody and circulating cytokeratin 18: anti-cytokeratin 18 antibody immune complexes in sera of patients with idiopathic pulmonary fibrosis

1 reference

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Identifiers

10.1038/SJ.BJC.6603220

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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