(Q35879955)

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Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression

scientific article published on 26 January 2012

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scholarly article

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21 January 2020

Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression (English)

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21 January 2020

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21 January 2020

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21 January 2020

Giancarlo Biagini

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21 January 2020

Ashley J Warman

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Ashley J Warman

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21 January 2020

Alexandre S Lawrenson

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Alexandre S Lawrenson

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21 January 2020

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Nicholas Fisher

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21 January 2020

Roslaini Abd Majid

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21 January 2020

Thomas Antoine

3

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21 January 2020

Mohammed Al-Helal

4

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21 January 2020

David J Johnson

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21 January 2020

Paul M O'Neill

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21 January 2020

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26 January 2012

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21 January 2020

Journal of Biological Chemistry

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21 January 2020

287

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21 January 2020

13

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21 January 2020

9731-9741

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21 January 2020

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships

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Molecular basis of resistance to cytochrome bc1 inhibitors

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Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

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Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

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Human disease-related mutations in cytochrome b studied in yeast

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Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo site inhibitor bound

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Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum

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Multisystem disorder associated with a missense mutation in the mitochondrial cytochrome b gene

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Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site

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Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite

1 reference

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Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

1 reference

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Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance

1 reference

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Re-examination of inhibitor resistance conferred by Qo-site mutations in cytochrome b using yeast as a model system.

1 reference

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1 reference

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QO site deficiency can be compensated by extragenic mutations in the hinge region of the iron-sulfur protein in the bc1 complex of Saccharomyces cerevisiae

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Elimination of the Disulfide Bridge in the Rieske Iron−Sulfur Protein Allows Assembly of the [2Fe-2S] Cluster into the Rieske Protein but Damages the Ubiquinol Oxidation Site in the Cytochrome bc1 Complex

1 reference

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Effect of inhibition of the bc1 complex on gene expression profile in yeast.

1 reference

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1 reference

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Conformationally linked interaction in the cytochrome bc(1) complex between inhibitors of the Q(o) site and the Rieske iron-sulfur protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22282497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proton-coupled electron transfer at the Q(o) site: what type of mechanism can account for the high activation barrier?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22282497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on cytochrome oxidase. 8. Preparation and some properties of cardiac cytochrome oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22282497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22282497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

dCTP levels are maintained in Plasmodium falciparum subjected to pyrimidine deficiency or excess

1 reference

https://pubmed.ncbi.nlm.nih.gov/22282497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.324319

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Europe PubMed Central

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21 January 2020

1 reference

Europe PubMed Central

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21 January 2020

1 reference

Europe PubMed Central

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21 January 2020

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