(Q35882299)

English

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation.

scientific article published on 12 March 2012

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scholarly article

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Europe PubMed Central

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25 January 2020

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation (English)

1 reference

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25 January 2020

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5

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25 January 2020

author name string

Hongwei Qin

1

1 reference

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25 January 2020

Wen-I Yeh

2

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25 January 2020

Patrizia De Sarno

3

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25 January 2020

Andrew T Holdbrooks

4

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25 January 2020

Michelle T Muldowney

6

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25 January 2020

Stephanie L Reynolds

7

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25 January 2020

Lora L Yanagisawa

8

1 reference

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25 January 2020

Thomas H Fox

9

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25 January 2020

Keun Park

10

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25 January 2020

Laurie E Harrington

11

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25 January 2020

Chander Raman

12

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25 January 2020

Etty N Benveniste

13

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25 January 2020

language of work or name

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publication date

12 March 2012

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25 January 2020

number of pages

6

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inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

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25 January 2020

109

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25 January 2020

13

1 reference

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25 January 2020

5004-5009

1 reference

Europe PubMed Central

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25 January 2020

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323949

11 July 2018

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

1 reference

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11 July 2018

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

1 reference

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11 July 2018

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

1 reference

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MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.

1 reference

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11 July 2018

Effector T cell plasticity: flexibility in the face of changing circumstances

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11 July 2018

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

1 reference

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11 July 2018

Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis

1 reference

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11 July 2018

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

1 reference

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11 July 2018

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

1 reference

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STATs in cancer inflammation and immunity: a leading role for STAT3

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Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology

1 reference

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11 July 2018

STAT3 in CD4+ T helper cell differentiation and inflammatory diseases

1 reference

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11 July 2018

SOCS1 and SOCS3 in the control of CNS immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323949

11 July 2018

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

1 reference

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11 July 2018

TGF-beta promotes Th17 cell development through inhibition of SOCS3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3323949

11 July 2018

Autoimmune T cell responses in the central nervous system

1 reference

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11 July 2018

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.

1 reference

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11 July 2018

Alternative activation of macrophages: an immunologic functional perspective

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11 July 2018

Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary

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Therapeutic targeting of Janus kinases

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Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

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11 July 2018

Cytokine signaling modules in inflammatory responses

1 reference

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11 July 2018

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

1 reference

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11 July 2018

SOCS proteins, cytokine signalling and immune regulation

1 reference

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11 July 2018

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

1 reference

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11 July 2018

Phenotype and prognosis in African-Americans with multiple sclerosis: a retrospective chart review.

1 reference

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11 July 2018

New vistas on macrophage differentiation and activation

1 reference

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

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Control of microglial neurotoxicity by the fractalkine receptor

1 reference

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

1 reference

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11 July 2018

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

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Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

1 reference

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11 July 2018

SOCS3 negatively regulates IL-6 signaling in vivo

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11 July 2018

Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis

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Axonal transection in the lesions of multiple sclerosis

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Early prognostic factors for disability in multiple sclerosis, a European multicenter study

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11 July 2018

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CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

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24 September 2018

Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

1 reference

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24 September 2018

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

1 reference

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Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis.

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24 September 2018

Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22411837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22411837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22411837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22411837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1117218109

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22411837%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

2012PNAS..109.5004Q

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22411837%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22411837%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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