(Q35884948)

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GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia

scientific article published in July 2004

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scholarly article

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Europe PubMed Central

10 August 2017

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Europe PubMed Central

GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia (English)

1 reference

Europe PubMed Central

10 August 2017

Alzheimer's disease

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Krista L Lanctôt

1

object named as

Krista L Lanctôt

1 reference

Europe PubMed Central

10 August 2017

author name string

Nathan Herrmann

2

1 reference

Europe PubMed Central

10 August 2017

Paolo Mazzotta

3

1 reference

Europe PubMed Central

10 August 2017

Lyla R Khan

4

1 reference

Europe PubMed Central

10 August 2017

Neil Ingber

5

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Europe PubMed Central

10 August 2017

language of work or name

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publication date

1 July 2004

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Europe PubMed Central

10 August 2017

Canadian Journal of Psychiatry

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Europe PubMed Central

10 August 2017

49

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Europe PubMed Central

10 August 2017

7

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Europe PubMed Central

10 August 2017

439-453

1 reference

Europe PubMed Central

10 August 2017

Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society

1 reference

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21 January 2018

The course of psychopathologic features in mild to moderate Alzheimer disease.

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21 January 2018

The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease.

1 reference

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21 January 2018

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

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21 January 2018

Role of serotonin in the behavioral and psychological symptoms of dementia

1 reference

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21 January 2018

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1 reference

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21 January 2018

Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited

1 reference

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21 January 2018

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

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21 January 2018

GABA receptor mechanisms in the central nervous system

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21 January 2018

GABA and hippocampal inhibition

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21 January 2018

Neurochemical substrates of rigidity and chorea in Huntington's disease

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21 January 2018

Benzodiazepines as antidepressants: does GABA play a role in depression?

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21 January 2018

GABA and brain abnormalities in schizophrenia.

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21 January 2018

GABA-ergic neurons and the neurobiology of schizophrenia and other psychoses

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21 January 2018

Offense produced by chemical stimulation of the anterior hypothalamus of the rat.

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21 January 2018

Behavioural responses of bicucculline methiodide injections into the ventral hypothalamus of freely moving, socially interacting rats.

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21 January 2018

Drugs and stimulus-bound attack

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21 January 2018

Effects of psychotherapeutic drugs on hypothalamic-induced hissing in cats

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21 January 2018

The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory

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21 January 2018

Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices.

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21 January 2018

GABA-transaminase in brain and blood platelets: basic and clinical aspects

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21 January 2018

The 'ABC' of GABA receptors: a brief review

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21 January 2018

The 'ABC' of GABA receptors

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21 January 2018

Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients.

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21 January 2018

Pharmacology of recombinant human GABA(A) receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay.

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21 January 2018

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

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21 January 2018

New insights into the mechanism of action of hypnotics

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21 January 2018

The glutamatergic system and Alzheimer's disease: therapeutic implications

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21 January 2018

Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison.

1 reference

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21 January 2018

Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease.

1 reference

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21 January 2018

Gamma-aminobutyric acid concentration in brain tissue at two stages of Alzheimer's disease

1 reference

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21 January 2018

Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type

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21 January 2018

A preliminary study of free amino acids in the postmortem temporal cortex from Alzheimer-type dementia patients.

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21 January 2018

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

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21 January 2018

A postmortem study of amino acid neurotransmitters in Alzheimer's disease.

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21 January 2018

A post-mortem study of the cholinergic and GABA systems in senile dementia.

1 reference

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21 January 2018

Hippocampal free amino acids in Alzheimer's disease.

1 reference

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21 January 2018

Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms

1 reference

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21 January 2018

Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.

1 reference

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21 January 2018

Changes in benzodiazepine receptors in Alzheimer-type dementia.

1 reference

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21 January 2018

Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors--an autoradiographic study.

1 reference

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21 January 2018

NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex.

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21 January 2018

The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia.

1 reference

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21 January 2018

[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.

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21 January 2018

A detailed anatomical analysis of neurotransmitter receptors in the putamen and caudate in Parkinson's disease and Alzheimer's disease

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Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology.

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21 January 2018

GABA transporters (GAT-1) in Alzheimer's disease.

1 reference

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21 January 2018

Pre- and postsynaptic neurochemical alterations in Alzheimer's disease

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21 January 2018

A disorder of cortical GABAergic innervation in Alzheimer's disease.

1 reference

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21 January 2018

Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease

1 reference

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21 January 2018

Cortical GABAB and GABAA receptors in Alzheimer's disease: a quantitative autoradiographic study.

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21 January 2018

Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease.

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21 January 2018

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

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21 January 2018

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

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21 January 2018

Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.

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21 January 2018

Increased gamma-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease.

1 reference

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21 January 2018

Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease.

1 reference

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21 January 2018

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.

1 reference

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21 January 2018

The effect of diazepam sedation on cerebral glucose metabolism in Alzheimer's disease as measured using positron emission tomography.

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21 January 2018

Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease.

1 reference

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21 January 2018

Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF.

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21 January 2018

Cerebrospinal fluid and plasma gamma-aminobutyric acid in Alzheimer's disease.

1 reference

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21 January 2018

CSF GABA in caregiver spouses of Alzheimer patients.

1 reference

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21 January 2018

Gamma-aminobutyric acid and homovanillic acid concentration in the CSF of patients with senile dementia of Alzheimer's type.

1 reference

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21 January 2018

Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders

1 reference

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21 January 2018

Cerebrospinal Fluid -Aminobutyric Acid Variations in Neurological Disorders

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21 January 2018

Alprazolam as an alternative to low-dose haloperidol in older, cognitively impaired nursing facility patients.

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Clonazepam for agitated patients with Alzheimer's disease.

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21 January 2018

Alleviating agitation, apprehension, and related symptoms in geriatric patients: A double-blind comparison of a phenothiazine and a benzodiazepien

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21 January 2018

Comparison of Thioridazine and Diazepam in the Control of Nonpsychotic Symptoms Associated with Senility: Double-Blind Study

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21 January 2018

Low-dose oral lorazepam administration in Alzheimer subjects and age-matched controls

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Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: a double-blind, randomized study in acutely agitated patients with dementia.

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21 January 2018

Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients.

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A preliminary study of carbamazepine in the treatment of assaultive patients with dementia.

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Withdrawal from controlled carbamazepine therapy followed by further carbamazepine treatment in patients with dementia

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21 January 2018

Efficacy and tolerability of carbamazepine for agitation and aggression in dementia

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21 January 2018

The effects of sodium valproate on disturbed behavior in dementia.

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21 January 2018

Valproic acid treatment of agitation in dementia.

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21 January 2018

An open trial of valproate for agitation in geriatric neuropsychiatric disorders

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21 January 2018

Valproate in the treatment of behavioral agitation in elderly patients with dementia.

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21 January 2018

Sodium valproate in the treatment of behavioral disturbance in dementia

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21 January 2018

Sodium valproate in the treatment of aggressive behavior in patients with dementia--a randomized placebo controlled clinical trial

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Occurrence of thrombocytopenia in psychiatric patients taking valproate

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Valproate-associated dysmyelopoiesis in elderly patients

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21 January 2018

Effectiveness of gabapentin for the treatment of behavioral disorders in dementia.

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21 January 2018

A Retrospective Chart Review of Gabapentin for the Treatment of Aggressive and Agitated Behavior in Patients With Dementias

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21 January 2018

Molecular and neuronal substrate for the selective attenuation of anxiety.

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21 January 2018

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

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21 January 2018

Recent advances in GABA research

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21 January 2018

Cerebellar GABA(A) receptors and anxiolytic action of diazepam.

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21 January 2018

Identifiers

10.1177/070674370404900705

0 references

1 reference

Europe PubMed Central

10 August 2017

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